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21 results

Gap What is the mechanism by which CD11c+ cells transport alpha-synuclein from brain to gut? rel 0.32

alpha-synuclein aggregates are contained within CD11c+ cells, but the cellular

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Gap Do CD11c+ cells actively uptake alpha-synuclein aggregates or acquire them through other mechanisms? rel 0.32

alpha-synuclein in the ileum, it's unclear whether these

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Gap Mechanisms of peripheral alpha-synuclein preformed fibril transcytosis across the blood-brain barrier rel 0.32

alpha-synuclein preformed fibrils (PFFs) cross the blood-brain barrier

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Gap GBA-alpha-synuclein bidirectional loop in Parkinson's rel 0.28

alpha-synuclein aggregation, but alpha-synuclein itself inhibits GBA activity

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Gap TREM2-dependent microglial processing of alpha-synuclein fibrils via AEP truncation rel 0.22

alpha-synuclein fibrils via TREM2 and AEP cleaves them to truncated

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Gap LRRK2 G2019S regulation of clusterin and impaired astrocyte uptake of alpha-synuclein fibrils rel 0.22

alpha-synuclein fibril ingestion due to dysregulated clusterin. However, the mechanism

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Gap What molecular mechanisms link VCP mutations to alpha-synuclein aggregation in MSP1 parkinsonism? rel 0.22

alpha-synuclein aggregation leading to parkinsonism, but the mechanistic pathway

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Gap How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synuclein aggregation and dopaminergic neuron survival via vagal nerve signaling in Parkinson disease rel 0.21

alpha-synuclein aggregation and dopaminergic neuron survival via vagal nerve

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Gap What molecular mechanisms distinguish DNAJB6 from DNAJB1 in suppressing α-synuclein aggregation? rel 0.10

Aggregation of Alpha-Synuclein in Cells. (None, None, PMID:31514384)

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Gap What molecular mechanisms cause aCSF-formed α-synuclein fibrils to lose stability when removed from their formation environment? rel 0.10

Alpha-Synuclein Fibril Strain in Artificial Cerebrospinal Fluid. (2026, Advanced

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Gap Which specific CSF molecular components are essential for maintaining disease-relevant α-synuclein fibril structure? rel 0.10

Alpha-Synuclein Fibril Strain in Artificial Cerebrospinal Fluid. (2026, Advanced

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Gap Why have previous in vitro studies failed to replicate disease-relevant α-synuclein fibril structures? rel 0.10

Alpha-Synuclein Fibril Strain in Artificial Cerebrospinal Fluid. (2026, Advanced

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Gap Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration rel 0.10

alpha-synuclein, TDP-43, and other neurodegenerative hallmarks? 5. Confounding

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Gap How does increased Akkermansia abundance specifically compromise intestinal barrier integrity in PD? rel 0.10

alpha-synuclein propagation, but the molecular mechanisms of mucin degradation

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Gap Does LRRK2-mediated lysosomal suppression contribute to alpha-synuclein accumulation and neuronal death in vivo? rel 0.10

While the study establishes LRRK2's role in suppressing lysosomal

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Gap What mechanisms link olfactory loss and color vision deficits to synucleinopathy progression? rel 0.10

alpha-synuclein pathology remain unclear. Elucidating these links could identify

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Gap How does gastrointestinal inflammation causally contribute to alpha-synuclein pathology and dopaminergic neuronal loss? rel 0.10

While the abstract establishes a bidirectional link between GI inflammation

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Gap What are the specific molecular mechanisms by which disease proteins disrupt Ca2+ homeostasis? rel 0.10

alpha-synuclein, and huntingtin adversely affect Ca2+ homeostasis by mechanisms

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Gap Peripheral-to-brain transport routes and tissue distribution of pathological neurodegeneration proteins rel 0.10

alpha-synuclein, and TDP-43 are found in peripheral tissues

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Gap Iron-dependent protein aggregation cross-talk in Alzheimer's and Parkinson's disease rel 0.10

alpha-synuclein fibrillization, or whether aggregation is a downstream consequence

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Gap Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation, and Therapeutic Strategies rel 0.10

alpha-synuclein aggregation, and dopaminergic neurodegeneration in Parkinson's disease

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