In mouse V1, VIP-expressing GABAergic neurons account for ~11% of cortical inte…

In mouse V1, VIP-expressing GABAergic neurons account for ~11% of cortical interneurons and are concentrated in the supragranular layers, with the majority of CR, VIP, ChAT and CCK neurons in layer 2/3 — establishing the laminar bias context for VIP morphological subtypes.

{
  "n": 0,
  "doi": "10.3389/neuro.05.003.2007",
  "claim": "In mouse V1, VIP-expressing GABAergic neurons account for ~11% of cortical interneurons and are concentrated in the supragranular layers, with the majority of CR, VIP, ChAT and CCK neurons in layer 2/3 — establishing the laminar bias context for VIP morphological subtypes.",
  "title": null,
  "cite_key": "Gonchar2008",
  "evidence": "Triple immunostaining for PV/CR/SOM/VIP/NPY/CCK/ChAT/NOS in adult mouse V1.",
  "effect_size": "VIP = 11% of GABAergic neurons; CR/VIP/ChAT enriched in superficial layers",
  "text_access": "fulltext",
  "study_system": "adult mouse V1",
  "_source_cluster": "cluster_03_morphology",
  "replication_status": "replicated",
  "_source_cluster_index": 29,
  "claim_source_sentence": "The next smaller groups expressed VIP (11%), NPY (8%) and CCK (5%), whereas ChAT and NOS accounted for only about 1% of GABAergic neurons (Table 2).",
  "replication_evidence_dois": [
    "10.1002/cne.22229",
    "10.1002/dneu.20853"
  ],
  "effect_size_source_sentence": "Figure 2 shows that the majority of CR, VIP, ChAT and CCK neurons were located in layer 2/3 and that these cells were significantly (p < 0.01 for comparisons of markers in layer 2/3 with markers in layers 5 and 6) less abundant in middle and deep layers."
}

[
  "paper:paper-35d664630898"
]

[
  {
    "ref": "paper:paper-35d664630898"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}