Details
- scope
- primary motor cortex (M1/MOp), human, marmoset, mouse
- section_id
- section_02
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-02-anatomy-primer
- source_kind
- review_finding
- source_path
- evidence/section_02_evidence_package.json
- source_span
- Few cell-type marker genes are conserved across species, revealing a short list of candidate genes and regulatory mechanisms that are responsible for conserved features of homologous cell types, such as the GABAergic chandelier cells.
- study_system
- primary motor cortex (M1/MOp), human, marmoset, mouse
- section_title
- 2. Mouse-cortex anatomy primer — areal map, layer structure, projection-class nomenclature (IT / PT / CT), tools available for E→E dissection (paired patch, Cre lines, two-photon-targeted patch, optogenetics, EM reconstruction)
- evidence_summary
- snRNA-seq, snATAC-seq, and snmC-seq across >450,000 single nuclei from human, marmoset, and mouse M1 with cross-species transcriptomic alignment.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-02-anatomy-primer
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- claim_text
Despite a broadly conserved cellular taxonomy of primary motor cortex across human, marmoset, and mouse, few cell-type marker genes are conserved across species, meaning mouse-defined marker-based identifiers cannot be directly transferred to other species without verification.
- raw_fields
{ "n": ">450,000 nuclei across three species", "doi": "10.1038/s41586-021-03465-8", "claim": "Despite a broadly conserved cellular taxonomy of primary motor cortex across human, marmoset, and mouse, few cell-type marker genes are conserved across species, meaning mouse-defined marker-based identifiers cannot be directly transferred to other species without verification.", "cite_key": "Bakken2021", "evidence": "snRNA-seq, snATAC-seq, and snmC-seq across >450,000 single nuclei from human, marmoset, and mouse M1 with cross-species transcriptomic alignment.", "effect_size": null, "text_access": "abstract_only", "study_system": "primary motor cortex (M1/MOp), human, marmoset, mouse", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "Few cell-type marker genes are conserved across species, revealing a short list of candidate genes and regulatory mechanisms that are responsible for conserved features of homologous cell types, such as the GABAergic chandelier cells.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "Few cell-type marker genes are conserved across species, revealing a short list of candidate genes and regulatory mechanisms that are responsible for conserved features of homologous cell types, such as the GABAergic chandelier cells." }- source_refs
[ "paper:paper-pm-34616062" ]
- evidence_refs
[ { "ref": "paper:paper-pm-34616062" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }