Around one thousand new Cre-driver tracer experiments in the Allen Mouse Brain…

Around one thousand new Cre-driver tracer experiments in the Allen Mouse Brain Connectivity Atlas yielded generalized axon-termination rules for corticocortical, thalamocortical and corticothalamic projections; a model assigning feedforward versus feedback connections placed mouse cortical and thalamic areas in only a shallow hierarchy.

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  "n": 1000,
  "doi": "10.1038/s41586-019-1716-z",
  "claim": "Around one thousand new Cre-driver tracer experiments in the Allen Mouse Brain Connectivity Atlas yielded generalized axon-termination rules for corticocortical, thalamocortical and corticothalamic projections; a model assigning feedforward versus feedback connections placed mouse cortical and thalamic areas in only a shallow hierarchy.",
  "cite_key": "Harris2019",
  "evidence": "~1,000 Cre-driver tracer experiments, layer- and projection-class-specific; model-assigned hierarchy is shallow in mouse cortex.",
  "effect_size": "~1,000 tracer experiments; shallow hierarchy of corticothalamic network",
  "text_access": "fulltext",
  "study_system": "Mouse cortex + thalamus tracer atlas (Cre-driver, brain-wide)",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "Through observations of axon termination patterns, we have derived a set of generalized anatomical rules to describe corticocortical, thalamocortical and corticothalamic projections.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "involving around a thousand new tracer experiments in the cortex and its main satellite structure, the thalamus."
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15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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