Details

scope
mouse cortico-thalamic connectivity (Cre-driver tract tracing)
claim_text
A hierarchical, layer-/cell-class-specific organization of corticocortical, thalamocortical and corticothalamic projections defines feedforward vs feedback positions across mouse cortical and thalamic areas.
section_id
section_06
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
effect_size
~1000 cell-class–specific tracer experiments
review_repo
ComputationalReviewLoops
section_ref
wiki_page:computationalreviewloops-06
source_kind
review_finding
source_path
evidence/section_06_evidence_package.json
source_span
We have built a model to assign connection patterns between areas as either feedforward or feedback, and generated testable predictions of hierarchical positions for individual cortical and thalamic areas and for cortical network modules.
study_system
mouse cortico-thalamic connectivity (Cre-driver tract tracing)
section_title
Thalamic Feedback: Closing the Loop
evidence_summary
Roughly one thousand additional Cre-driver tract-tracing experiments resolving thalamus-included hierarchies in the mouse cortex.
review_bundle_ref
analysis_bundle:ab-d49e54403ef9
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-d49e54403ef9
source_artifact_ref
wiki_page:computationalreviewloops-06
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
commit_sha
0632aae8abc141909207fe91f6349b9e36489c3b
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
raw_fields
{
  "n": 1000,
  "doi": "10.1038/s41586-019-1716-z",
  "claim": "A hierarchical, layer-/cell-class-specific organization of corticocortical, thalamocortical and corticothalamic projections defines feedforward vs feedback positions across mouse cortical and thalamic areas.",
  "cite_key": "Harris2019",
  "evidence": "Roughly one thousand additional Cre-driver tract-tracing experiments resolving thalamus-included hierarchies in the mouse cortex.",
  "effect_size": "~1000 cell-class–specific tracer experiments",
  "text_access": "fulltext",
  "study_system": "mouse cortico-thalamic connectivity (Cre-driver tract tracing)",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We have built a model to assign connection patterns between areas as either feedforward or feedback, and generated testable predictions of hierarchical positions for individual cortical and thalamic areas and for cortical network modules.",
  "replication_evidence_dois": [
    "10.1038/nature13186",
    "10.1038/nn.4197"
  ],
  "effect_size_source_sentence": "Here we describe a major expansion of the Allen Mouse Brain Connectivity Atlas resource1, involving around a thousand new tracer experiments in the cortex and its main satellite structure, the thalamus."
}
source_refs
[
  "paper:paper-259a50694faa"
]
evidence_refs
[
  {
    "ref": "paper:paper-259a50694faa"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

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