- raw_fields
{
"n": 0,
"doi": "10.1016/j.celrep.2025.116792",
"claim": "Layer 6 corticothalamic neurons form functional AMPA-receptor-containing synapses preferentially onto PV interneurons through cell-type-biased synaptogenesis rather than pruning",
"evidence": "Layer 6 corticothalamic neurons form functional AMPA-receptor-containing synapses preferentially onto PV interneurons through cell-type-biased synaptogenesis rather than pruning",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mouse neocortex, layers 4 and 6",
"replication_status": "replication_unknown",
"claim_source_sentence": "We find that L6CThNs form functional AMPA-receptor-containing synapses preferentially onto PV interneurons. Silent L6CThN synapses are not detected. Our findings show that cell-type-biased synaptogenesis underlies the formation of functional cell-type-specific excitatory connections in the neocortex.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-d8c260dd6b59"
]
- source_span
We find that L6CThNs form functional AMPA-receptor-containing synapses preferentially onto PV interneurons. Silent L6CThN synapses are not detected. Our findings show that cell-type-biased synaptogenesis underlies the formation of functional cell-type-specific excitatory connections in the neocortex.
- evidence_refs
[
{
"ref": "paper:paper-d8c260dd6b59"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}