Details
- scope
- Mouse V1 (visual cortex); layer L2/3/L4
- claim_text
- L2/3 excitatory neurons in mouse V1 form a continuous transcriptomic gradient from pial surface to L4 boundary, paralleled by ~30,000 ATAC-accessible regions varying continuously along this axis.
- section_id
- section_06
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
- effect_size
- ~30,000 genomic regions vary continuously along the L2/3 axis
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-06-connectomic-micons
- source_kind
- review_finding
- source_path
- evidence/section_06_evidence_package.json
- study_system
- Mouse V1 (visual cortex); layer L2/3/L4
- section_title
- 6. Connectomic resolution — MICrONS mouse V1/HVA millimetre-scale EM volume; pyramidal-pyramidal wiring statistics derived from it; reconciliation with paired-recording estimates
- evidence_summary
- Single-cell RNA-seq plus spatial transcriptomics combined with paired EASI-FISH and barcoded AAV mapping in mouse V1.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-06-connectomic-micons
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- raw_fields
{ "n": 30000, "doi": "10.1101/2025.09.22.677893", "claim": "L2/3 excitatory neurons in mouse V1 form a continuous transcriptomic gradient from pial surface to L4 boundary, paralleled by ~30,000 ATAC-accessible regions varying continuously along this axis.", "cite_key": "Yoo2025", "evidence": "Single-cell RNA-seq plus spatial transcriptomics combined with paired EASI-FISH and barcoded AAV mapping in mouse V1.", "effect_size": "~30,000 genomic regions vary continuously along the L2/3 axis", "text_access": "fulltext", "study_system": "Mouse V1 (visual cortex); layer L2/3/L4", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "Single-cell profiling and spatial transcriptomics studies have shown that L2/3 excitatory neurons in the mouse primary visual cortex (V1) and other sensory cortices form a continuum of cell identities from the pial surface to the boundary between L2/3 and L4.", "source_provenance_status": "ok", "replication_evidence_dois": [], "effect_size_source_sentence": "A similar structure is also evident in ATAC-seq data at P21, with chromatin accessibility profiles at ~30,000 genomic regions varying continuously along the L2/3 transcriptomic continuum (–,–)." }- source_refs
[ "paper:paper-694de09631a7" ]
- source_span
Single-cell profiling and spatial transcriptomics studies have shown that L2/3 excitatory neurons in the mouse primary visual cortex (V1) and other sensory cortices form a continuum of cell identities from the pial surface to the boundary between L2/3 and L4.
- evidence_refs
[ { "ref": "paper:paper-694de09631a7" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }