In mouse secondary motor cortex (M2/MOs), L5 IT cells preferring to innervate l…

In mouse secondary motor cortex (M2/MOs), L5 IT cells preferring to innervate layer 1 in target areas project to a broader set of cortical regions (including perirhinal and auditory cortex) and a larger striatal volume, more often express ER81/ETV1 in upper L5 (L5a), and have lower input resistance than contra-M2-projecting L5 IT cells.

{
  "n": null,
  "doi": "10.1093/cercor/bhac052",
  "claim": "In mouse secondary motor cortex (M2/MOs), L5 IT cells preferring to innervate layer 1 in target areas project to a broader set of cortical regions (including perirhinal and auditory cortex) and a larger striatal volume, more often express ER81/ETV1 in upper L5 (L5a), and have lower input resistance than contra-M2-projecting L5 IT cells.",
  "cite_key": "Im2022",
  "evidence": "Analysis of MouseLight single-neuron reconstructions combined with retrograde labelling, immunohistochemistry for ER81 and whole-cell recordings in mouse MOs.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse secondary motor cortex L5a IT cells defined by projection preference (L1-preferring vs contra-M2)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Our findings suggest that M2-L5a IT L1-preferring cells exhibit stronger ER81 expression and broader cortical/striatal projection fields than do cells that do not preferentially target L1.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-e55711a2961a"
]

[
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  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}