In mouse secondary motor cortex L5 intratelencephalic (IT) neurons, those prefe…

In mouse secondary motor cortex L5 intratelencephalic (IT) neurons, those preferentially innervating layer 1 form a distinct subtype with broader cortical projection patterns, ER81/ETV1 expression and lower input resistance, and are preferentially synaptically connected to other perirhinal-projecting L5 IT cells.

{
  "n": 0,
  "doi": "10.1093/cercor/bhac052",
  "claim": "In mouse secondary motor cortex L5 intratelencephalic (IT) neurons, those preferentially innervating layer 1 form a distinct subtype with broader cortical projection patterns, ER81/ETV1 expression and lower input resistance, and are preferentially synaptically connected to other perirhinal-projecting L5 IT cells.",
  "cite_key": "Im2022",
  "evidence": "Combined MouseLight single-neuron tracing analysis and slice patch recordings of retrogradely labeled L5 IT cells in mouse M2.",
  "effect_size": "qualitative — distinct projection, transcriptomic and electrophysiological subtype of L5 IT cells",
  "text_access": "abstract_only",
  "study_system": "mouse secondary motor cortex (M2) L5 IT cells",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Here we show that L5 IT cells participating in feedback connections to layer 1 (L1) exhibit distinct projection patterns, genetic profiles, and electrophysiological properties relative to other L5 IT cells.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1523/JNEUROSCI.0772-11.2011",
    "10.1093/cercor/bhx276"
  ],
  "effect_size_source_sentence": "The perirhinal region-projecting L5a IT cells were synaptically connected to each other and displayed lower input resistance than contra-M2 projecting IT cells including L1-preferring and nonpreferring cells."
}

[
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]

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    "Local review repositories are read-only inputs.",
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