Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing spatial memory hypotheses, sorted by Composite score.
Social Memory Network Enhancement Therapy
Oxytocin receptor (OXTR), mirror neuron networks spatial memory 46%The Oxytocin Receptor: From Intracellular Signaling to Behavior.
hyp-SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4-4Metabolic Memory Support Therapy
AMPK, PGC-1α, mitochondrial complex proteins spatial memory 46%α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway.
hyp-SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4-1Circadian-Spatial Memory Coupling for Navigation Disorders
CLOCK, BMAL1, hippocampal place cells spatial memory 46%BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells.
hyp-SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4-3Stress-Resilient Memory Formation Protocol
FKBP5, glucocorticoid receptor (GR), BDNF spatial memory 46%Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
hyp-SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4-2Developmental Critical Period Extension for Memory Recovery
PSD-95, CREB, perineuronal net components spatial memory 46%The advances of post-stroke depression: 2021 update.
hyp-SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4-6Magnetic Field Stimulation for Memory Consolidation
Cryptochromes (CRY1, CRY2), magnetoreceptor proteins spatial memory 46%In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein.
hyp-SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4-7Epigenetic Memory Engram Therapy for Alzheimer's Disease
DNMT3A, CREB-binding protein (CBP) spatial memory 46%55% posterior · 1 signalThe role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease.
hyp-SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4-5