All knowledge_gaps
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Smoke: how does TREM2 modulate microglial response?
smoke test gap
- Where does TREM2 act in microglia?
- Where does TREM2 act in microglia?
- Implementation gaps in the 2024 Lancet dementia prevention recommendations for underserved populations
PMID:4401164724 (Lancet 2024 Dementia Commission) identified 14 modifiable risk factors for dementia and recommended population-wide and individualized interventions. However, critical implementation gaps remain: how to…
- Prion protein species barrier mechanisms and their relevance to sporadic neurodegenerative disease
PMID:38918277 reviewed prion protein (PrP) cross-species transmission and the substantial knowledge gap in understanding how PrP misfolding relates to other neurodegenerative proteinopathies. Whether sporadic AD, PD, and…
- Sex-specific adrenergic receptor mechanisms driving sex differences in Alzheimer's disease
PMID:4392059707 investigated sex differences in Alzheimer's disease. The noradrenergic system shows marked sex differences in AD risk and progression. How gonadal hormones interact with adrenergic signaling to modulate m…
- Neu1 and PPCA lysosomal complex regulation of APP metabolism and amyloidogenesis
PMID:10.1101/2025.04.28.651121 identified the Neu1-PPCA lysosomal complex as a critical regulator of APP sialylation and processing, with Neu1 deficiency enhancing amyloidogenic cleavage. The mechanisms by which Neu1/PPC…
- Retinal microglia S100A9-mediated NLRP3 inflammasome activation as a systemic inflammation link to neurodegeneration
PMID:10.1101/2024.10.30.621160 identified retinal microglia-derived S100A9 activating NLRP3 inflammasome in obese pig retina. S100A9 is also elevated in AD brains. Whether retinal S100A9-NLRP3 signaling reflects or drive…
- Ultrastructural and molecular drivers of dark microglia formation in neurodegeneration
PMID:39719704 identified dark microglia as a distinct ultrastructurally-defined microglia subset linked to pathological synapse loss in AD. However, what distinguishes dark microglia ultrastructurally from disease-associ…
- Mechanistic pathways by which microbiome-based interventions influence neurodegenerative disease progression
PMID:41459056 reviewed that probiotics, prebiotics, synbiotics, and postbiotics can modulate the microbiota-gut-brain axis to influence AD, PD, MS, ALS, and HD. However, which specific microbial species, metabolites (SCF…
- Iron-dependent protein aggregation cross-talk in Alzheimer's and Parkinson's disease
PMID:40427409 described how iron accumulation may fuel disease-specific protein aggregation in AD and PD. However, whether iron directly catalyzes amyloid-beta or alpha-synuclein fibrillization, or whether aggregation is…