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What cell-type-specific gene regulatory networks mediate the DPP6 GWAS signal for cognitive decline in Parkinson's disease — do they converge on synaptic plasticity pathways in hippocampal versus prefrontal neurons, and is DPP6 expression altered in prodromal PD before motor symptoms?
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DPP6-linked neuronal regulatory networks controlling synaptic excitability and cognitive resilience in PD should produce a measurable proximal phenotype before late disease pathology. The decisive test is cell-type eQTL colocalization, enhancer perturbation, and prodromal PD single-nucleus validation in hippocampal and prefrontal neurons.
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cognitive-decline, topic:memory, topic:early-detection ## Overview ```mermaid flowchart
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