- claim_text
Anatomical tracing and electrophysiology in rats show that ventromedial (limbic) striatal stimulation inhibits nigrostriatal dopamine neurons projecting to dorsolateral motor striatum, providing direct functional evidence for the limbic-to-motor ascending dopamine spiral.
- raw_fields
{
"n": 0,
"doi": "10.1002/jnr.24242",
"claim": "Anatomical tracing and electrophysiology in rats show that ventromedial (limbic) striatal stimulation inhibits nigrostriatal dopamine neurons projecting to dorsolateral motor striatum, providing direct functional evidence for the limbic-to-motor ascending dopamine spiral.",
"cite_key": "Wouterlood2018",
"evidence": "Combined anterograde+retrograde tracing with confocal microscopy and orthodromic/antidromic stimulation in rat ventral mesencephalon identified close appositions and inhibitory responses, supporting Haber's spiral via nigrostriatal dopamine.",
"effect_size": "",
"text_access": "fulltext",
"study_system": "rat, dual-tracer + electrophysiology",
"source_cluster_id": "cluster_06",
"replication_status": "replication_unknown",
"claim_source_sentence": "Our results strongly suggest a functional link between ventromedial, emotional-motivational striatum, and the sensorimotor dorsal striatum via dopaminergic nigrostriatal neurons.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-30d25c353458"
]
- evidence_refs
[
{
"ref": "paper:paper-30d25c353458"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}- evidence_summary
Combined anterograde+retrograde tracing with confocal microscopy and orthodromic/antidromic stimulation in rat ventral mesencephalon identified close appositions and inhibitory responses, supporting Haber's spiral via nigrostriatal dopamine.