- claim_text
In-vivo two-photon imaging in mouse V1 showed that during visual stimulation locomotion increases activity of VIP, SST and PV interneurons simultaneously — directly contradicting the simple VIP→SST disinhibition model — and that locomotion modulation is context-dependent, with the highest proportion of context-sensitive cells among SST neurons.
- raw_fields
{
"n": null,
"doi": "10.7554/elife.14985",
"claim": "In-vivo two-photon imaging in mouse V1 showed that during visual stimulation locomotion increases activity of VIP, SST and PV interneurons simultaneously — directly contradicting the simple VIP→SST disinhibition model — and that locomotion modulation is context-dependent, with the highest proportion of context-sensitive cells among SST neurons.",
"title": null,
"cite_key": "Pakan2016",
"evidence": "In vivo two-photon Ca2+ imaging of VIP/SST/PV cells in mouse V1 across locomotion and visual stimulation conditions.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse V1 in vivo 2-photon Ca2+ imaging",
"target_section": "section_05",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "single_study",
"_source_cluster_index": 70,
"claim_source_sentence": "Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model."
}- source_refs
[
"paper:paper-acf576c0a2ed"
]
- source_span
Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.
- evidence_refs
[
{
"ref": "paper:paper-acf576c0a2ed"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}