Details
- scope
- vip-interneurons
- section_id
- section_08
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
- effect_size
- Most VIP/PV remained locomotion-responsive in darkness; SST cells lost responsiveness in darkness.
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-08-in-vivo-behavior
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- Locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.
- section_title
- In Vivo Function During Behavior
- evidence_summary
- Two-photon Ca2+ imaging of L2/3 and L4 interneurons in V1 during running.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- supported
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-08-in-vivo-behavior
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Locomotion in mouse V1 increases activity of VIP, SST and PV interneurons during visual stimulation, with context-dependent (visual vs. dark) responsiveness; this contests a pure VIP→SST→Pyr disinhibition model and instead implicates parallel state recruitment of all interneuron classes.
- raw_fields
{ "n": null, "doi": "10.7554/elife.14985", "year": "2016", "claim": "Locomotion in mouse V1 increases activity of VIP, SST and PV interneurons during visual stimulation, with context-dependent (visual vs. dark) responsiveness; this contests a pure VIP→SST→Pyr disinhibition model and instead implicates parallel state recruitment of all interneuron classes.", "title": "Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex", "journal": "", "species": "mouse", "cite_key": "Pakan2016", "evidence": "Two-photon Ca2+ imaging of L2/3 and L4 interneurons in V1 during running.", "effect_size": "Most VIP/PV remained locomotion-responsive in darkness; SST cells lost responsiveness in darkness.", "text_access": "fulltext", "_source_cluster": "cluster_13_neuromodulation", "replication_status": "supported", "_source_cluster_index": 23, "claim_source_sentence": "Locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.", "replication_evidence_dois": [ "10.1016/j.neuron.2018.03.037", "10.1016/j.cell.2014.01.050" ], "effect_size_source_sentence": "In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive." }- source_refs
[ "paper:paper-acf576c0a2ed" ]
- evidence_refs
[ { "ref": "paper:paper-acf576c0a2ed" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }