Details
- scope
- mouse neocortex slice (5-HT3A:GFP)
- section_id
- section_06
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
- effect_size
- VIP cluster n=22, NPY cluster n=31; 16/22 (73%) VIP-cluster cells express VIP mRNA
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-06-synaptic-properties
- source_kind
- review_finding
- source_path
- evidence/section_06_evidence_package.json
- source_span
- The VIP-cluster of 5-HT 3A Interneurons Unsupervised clustering discriminated another group of cells characterized by a high occurrence of VIP mRNA ( n = 16/22, 73%).
- study_system
- mouse neocortex slice (5-HT3A:GFP)
- section_title
- Synaptic Properties and Connectivity
- evidence_summary
- Whole-cell patch-clamp + scRT-PCR + GFP transgenic 5HT3a:GFP mice; unsupervised clustering on 53 cells.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-06-synaptic-properties
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
5-HT3A receptor expression demarcates two electrophysiologically distinct subclasses of cortical CGE-derived interneurons: a VIP-expressing bipolar/bitufted cluster (n=22) and an NPY-expressing cluster (n=31) with more complex dendrites; ~73% of VIP-cluster cells co-express VIP mRNA, forming the principal molecular framework for 5HT3aR+ inhibition.
- raw_fields
{ "n": 53, "doi": "10.1093/cercor/bhp310", "claim": "5-HT3A receptor expression demarcates two electrophysiologically distinct subclasses of cortical CGE-derived interneurons: a VIP-expressing bipolar/bitufted cluster (n=22) and an NPY-expressing cluster (n=31) with more complex dendrites; ~73% of VIP-cluster cells co-express VIP mRNA, forming the principal molecular framework for 5HT3aR+ inhibition.", "title": null, "cite_key": "Vucurovic2010", "evidence": "Whole-cell patch-clamp + scRT-PCR + GFP transgenic 5HT3a:GFP mice; unsupervised clustering on 53 cells.", "effect_size": "VIP cluster n=22, NPY cluster n=31; 16/22 (73%) VIP-cluster cells express VIP mRNA", "text_access": "fulltext", "study_system": "mouse neocortex slice (5-HT3A:GFP)", "_source_cluster": "cluster_05_synaptic_connectivity", "replication_status": "replicated", "_source_cluster_index": 19, "claim_source_sentence": "The VIP-cluster of 5-HT 3A Interneurons Unsupervised clustering discriminated another group of cells characterized by a high occurrence of VIP mRNA ( n = 16/22, 73%).", "replication_evidence_dois": [ "10.1523/jneurosci.22-17-07389.2002" ], "effect_size_source_sentence": "Unsupervised clustering discriminated another group of cells characterized by a high occurrence of VIP mRNA ( n = 16/22, 73%)." }- source_refs
[ "paper:paper-0336a131683f" ]
- evidence_refs
[ { "ref": "paper:paper-0336a131683f" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }