VIP-cluster interneurons in juvenile S1 show two distinct intrinsic firing beha…

VIP-cluster interneurons in juvenile S1 show two distinct intrinsic firing behaviors: 68% (15/22) are adapting and 32% (7/22) are bursting; the adapting subset displays a characteristic post-spike sequence of first AHP → afterdepolarization (ADP) → late AHP after the first 2 action potentials in 8/15 cells — a signature seldom seen in PV or SST cells.

{
  "n": 22,
  "doi": "10.1093/cercor/bhp310",
  "claim": "VIP-cluster interneurons in juvenile S1 show two distinct intrinsic firing behaviors: 68% (15/22) are adapting and 32% (7/22) are bursting; the adapting subset displays a characteristic post-spike sequence of first AHP → afterdepolarization (ADP) → late AHP after the first 2 action potentials in 8/15 cells — a signature seldom seen in PV or SST cells.",
  "title": null,
  "cite_key": "Vucurovic2010",
  "evidence": "whole-cell patch (Lee 2010 5HT3a:GFP)",
  "effect_size": "Adapting 68% (15/22); bursting 32% (7/22); ADP+late AHP in 8/15 adapting",
  "text_access": "fulltext",
  "study_system": "juvenile mouse S1; whole-cell patch",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 86,
  "claim_source_sentence": "Neurons of the VIP-cluster exhibit 2 types of firing behavior, adapting (n = 15/22, 68%) or bursting (n = 7/22, 32%).",
  "replication_evidence_dois": [
    "10.1093/cercor/bhv202"
  ],
  "effect_size_source_sentence": "Indeed, the first 2 action potentials of adapting VIP were followed by a first AHP component, an ADP, and a late AHP component ( n = 8/15)."
}

[
  "paper:paper-0336a131683f"
]

[
  {
    "ref": "paper:paper-0336a131683f"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}