Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex.

{
  "n": null,
  "doi": "10.1002/cne.23875",
  "claim": "Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex.",
  "cite_key": "Tantirigama2015",
  "evidence": "The mature cerebral cortex contains a wide diversity of neuron phenotypes. This diversity is specified during development by neuron-specific expression of key transcription factors, some of which are retained for the life of the animal. One of these key developmental transcription factors that is also retained in the adult is Fezf2, but the neuron types expressing it in the mature cortex are unknown. With a validated Fezf2-Gfp reporter mouse, whole-cell electrophysiology with morphology reconstruction, cluster analysis, in vivo retrograde labeling, and immunohistochemistry, we identify a heter",
  "effect_size": null,
  "text_access": "abstract",
  "study_system": "mouse (retrograde tracing, electrophysiology)",
  "source_cluster_id": "cluster_03",
  "replication_status": "unknown",
  "claim_source_sentence": "Retrograde labeling confirmed the former type to include corticospinal projection neurons (CSpPNs) and corticothalamic projection neurons (CThPNs), whereas the latter type included crossed corticostriatal projection neurons (cCStrPNs) and crossed-corticocortical projection neurons (cCCPNs).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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  "paper:paper-89006181f9d5"
]

Retrograde labeling confirmed the former type to include corticospinal projection neurons (CSpPNs) and corticothalamic projection neurons (CThPNs), whereas the latter type included crossed corticostriatal projection neurons (cCStrPNs) and crossed-corticocortical projection neurons (cCCPNs).

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The mature cerebral cortex contains a wide diversity of neuron phenotypes. This diversity is specified during development by neuron-specific expression of key transcription factors, some of which are retained for the life of the animal. One of these key developmental transcription factors that is also retained in the adult is Fezf2, but the neuron types expressing it in the mature cortex are unknown. With a validated Fezf2-Gfp reporter mouse, whole-cell electrophysiology with morphology reconstruction, cluster analysis, in vivo retrograde labeling, and immunohistochemistry, we identify a heter