Details

scope
mouse neocortex
claim_text
These results reveal a state-dependent laminar influence of Sst interneuron-mediated inhibition, with implications for the compartmentalized regulation of dendritic signaling in the mammalian neocortex.
section_id
section_13
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-13-conclusion
source_kind
review_finding
source_path
evidence/section_13_evidence_package.json
source_span
These results reveal a state-dependent laminar influence of Sst interneuron-mediated inhibition, with implications for the compartmentalized regulation of dendritic signaling in the mammalian neocortex.
study_system
mouse neocortex
section_title
Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
evidence_summary
Layer-specific modulation of neocortical dendritic inhibition during active wakefulness
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
replicated
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-13-conclusion
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": null,
  "doi": "10.1126/science.aag2599",
  "year": "2017",
  "claim": "These results reveal a state-dependent laminar influence of Sst interneuron-mediated inhibition, with implications for the compartmentalized regulation of dendritic signaling in the mammalian neocortex.",
  "title": null,
  "journal": "Science (New York, N.Y.)",
  "cite_key": "Munoz2017",
  "evidence": "Layer-specific modulation of neocortical dendritic inhibition during active wakefulness",
  "effect_size": null,
  "text_access": "abstract_only",
  "first_author": "Muñoz",
  "study_system": "mouse neocortex",
  "_source_cluster": "cluster_06_disinhibition_circuit",
  "author_list_short": "Muñoz, Tremblay, Levenstein",
  "replication_status": "replicated",
  "_source_cluster_index": 8,
  "claim_source_sentence": "These results reveal a state-dependent laminar influence of Sst interneuron-mediated inhibition, with implications for the compartmentalized regulation of dendritic signaling in the mammalian neocortex.",
  "replication_evidence_dois": [
    "10.1126/science.1254126",
    "10.1038/nn.4554",
    "10.1016/j.neuron.2015.06.021"
  ],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-3f5bd9932217"
]
evidence_refs
[
  {
    "ref": "paper:paper-3f5bd9932217"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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