Details

scope
mouse V1
claim_text
We show that in cortical layers 2/3 and 5 parvalbumin (Pvalb), somatostatin (Sst), and vasoactive intestinal peptide (VIP) expressing interneurons interact via a simple and complementary connectivity scheme.
section_id
section_13
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
effect_size
80% of
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-13-conclusion
source_kind
review_finding
source_path
evidence/section_13_evidence_package.json
source_span
We show that in cortical layers 2/3 and 5 parvalbumin (Pvalb), somatostatin (Sst), and vasoactive intestinal peptide (VIP) expressing interneurons interact via a simple and complementary connectivity scheme.
study_system
mouse V1
section_title
Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
evidence_summary
Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-13-conclusion
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": null,
  "doi": "10.1038/nn.3446",
  "year": "2013",
  "claim": "We show that in cortical layers 2/3 and 5 parvalbumin (Pvalb), somatostatin (Sst), and vasoactive intestinal peptide (VIP) expressing interneurons interact via a simple and complementary connectivity scheme.",
  "title": null,
  "journal": "Nature neuroscience",
  "cite_key": "Pfeffer2013",
  "evidence": "Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons",
  "effect_size": "80% of",
  "text_access": "fulltext",
  "first_author": "Pfeffer",
  "study_system": "mouse V1",
  "_source_cluster": "cluster_06_disinhibition_circuit",
  "author_list_short": "Pfeffer, Xue, He",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 0,
  "claim_source_sentence": "We show that in cortical layers 2/3 and 5 parvalbumin (Pvalb), somatostatin (Sst), and vasoactive intestinal peptide (VIP) expressing interneurons interact via a simple and complementary connectivity scheme.",
  "replication_evidence_dois": [
    "10.1038/nature12676",
    "10.1038/nn.3544",
    "10.1016/j.cell.2014.01.050"
  ],
  "effect_size_source_sentence": "These three lines expressed Cre in three largely non-overlapping populations of interneurons that, together, represent approximately 80% of interneurons in primary visual cortex."
}
source_refs
[
  "paper:paper-1659c2dc5d60"
]
evidence_refs
[
  {
    "ref": "paper:paper-1659c2dc5d60"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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