Atlas · Knowledge gaps
Knowledge gaps queue
Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.
8
open gaps
| # | Title | Status | Priority | Domain | Created | |
|---|---|---|---|---|---|---|
| 1 | Can the miR-130a/TGFβ predictive assay be validated across larger, diverse pati… The ROC analysis was performed on small groups (9 patients each), and broader validation is needed to confirm the clinical utility of this predictive approach. … gap-pubmed-20260410-155300-0e2a880c | open | 0.840 | translational medicine | 2026-04-10 | Open → |
| 2 | How do species differences in P2RX7 function between rodents and humans affect… The debate noted significant functional differences in P2RX7 between rodent models and human microglia. These differences could explain preclinical-clinical tra… gap-debate-20260410-112451-3591c4e9 | open | 0.800 | translational medicine | 2026-04-10 | Open → |
| 3 | How does SV2A glycosylation status predict levetiracetam treatment response in… The debate suggested glycosylation defects could explain variable levetiracetam efficacy but provided no patient stratification data. This relationship could en… gap-debate-20260417-033203-16b16415 | open | 0.800 | translational medicine | 2026-04-17 | Open → |
| 4 | What obstacles prevent EV-based treatments from progressing to clinical trials… The abstract mentions that 'some obstacles remain that prevent their progression into clinics' despite EVs being deemed safe for human use. Identifying these sp… gap-pubmed-20260410-182921-2680c120 | open | 0.760 | translational medicine | 2026-04-10 | Open → |
| 5 | What is the therapeutic window between effective TDP-43 modulation and disrupti… All participants acknowledged that TDP-43 has critical normal functions in RNA metabolism, but no safety margins were established for therapeutic intervention. … gap-debate-20260410-095612-fcf9ed76 | open | 0.750 | translational medicine | 2026-04-10 | Open → |
| 6 | What are validated biomarkers for measuring senescent cell clearance and target… The Expert noted that senolytics lack validated biomarkers for in vivo target engagement, making clinical development nearly impossible. This represents a criti… gap-debate-20260410-112619-c9ebbe41 | open | 0.750 | translational medicine | 2026-04-10 | Open → |
| 7 | What is the therapeutic window for blocking tau propagation before irreversible… While intervention strategies were proposed, the debate didn't address timing considerations or whether there's a point of no return where blocking spread becom… gap-debate-20260412-094630-d15b2ac1 | open | 0.750 | translational medicine | 2026-04-12 | Open → |
| 8 | How do tissue-specific senescence patterns affect the universal applicability o… While hypotheses focused on general cellular mechanisms, the debate noted tissue-specific mitochondrial requirements and heterogeneity without resolving how thi… gap-debate-20260410-105355-5519d65a | open | 0.700 | translational medicine | 2026-04-10 | Open → |