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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Debate is the amyloid cascade hypothesis still important rel 1.00

is the amyloid cascade hypothesis still important

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Debate Is the amyloid cascade hypothesis still the best explanation for AD? rel 1.00

Is the amyloid cascade hypothesis still the best explanation for AD?

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Debate Is the amyloid cascade hypothesis still the best explanation for AD? rel 1.00

Is the amyloid cascade hypothesis still the best explanation for AD?

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Debate is the amyloid cascade still tractable rel 1.00

is the amyloid cascade still tractable

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Debate Is the amyloid hypothesis still tractable? rel 1.00

Is the amyloid hypothesis still tractable?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate what is the root cause of alzheimer's rel 0.75

what is the root cause of alzheimer's

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Debate what is the root cause of alzheimer's rel 0.75

what is the root cause of alzheimer's

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Debate What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline? rel 0.75

What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline?

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Debate what role does microglial TREM2 play in Alzheimer disease pathology rel 0.75

what role does microglial TREM2 play in Alzheimer disease pathology

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Gap Do enhanced brain penetration strategies alter amyloid clearance kinetics sufficiently to overcome the disputed amyloid hypothesis limitations? rel 0.50

amyloid targeting remains valid with better penetration, but the debate

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Gap Why does reduced microglial amyloid engulfment not worsen amyloid pathology in this model? rel 0.50

amyloid clearance is always beneficial and suggests complex amyloid-cognition

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Gap How do functional amyloids like SST influence pathological amyloid aggregation in vivo? rel 0.50

amyloids can mutually influence aggregation, but the physiological relevance and mechanisms

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Gap What mechanisms cause the diminishing effect of amyloid on tau spread beyond a critical threshold? rel 0.50

amyloid's potentiating effect on tau propagation diminishes at higher

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Gap How do the identified platelet protein candidates (ATP6V0C, AP4B1, RAB2B, etc.) functionally relate to brain amyloid deposition? rel 0.40

amyloid deposition, the functional connection between their platelet expression and brain

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Gap How does amyloid mechanistically facilitate tau propagation from entorhinal cortex to neocortex? rel 0.40

amyloid modifies the relationship between initial tau and subsequent spread

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Gap How do lysosomal hydrolase redistributions lead to neurotoxic amyloid peptide overproduction? rel 0.40

amyloid overproduction, but the mechanistic link between hydrolase mislocalization and amyloid

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Gap Why does plasma p-tau181 show stronger correlation with amyloid than tau pathology despite being a tau biomarker? rel 0.40

amyloid (ρ=0.45) than tau (ρ=0.25), which is counterintuitive

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Gap How does apoE specifically promote vascular versus parenchymal amyloid deposition? rel 0.40

amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic

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Gap Why does amyloid reduction correlate with tau biomarkers but not neurofilament light chain? rel 0.40

amyloid and reduced p-tau217/p-tau181 but no correlation with

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Gap What mechanisms drive endomembrane system organization upregulation specifically in amyloid-positive MCI and AD platelets? rel 0.40

amyloid-positive states. Understanding this mechanism could reveal how peripheral

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Gap How does neuronal cholesterol accumulation mechanistically promote amyloid pathology downstream of CHCHD6 loss? rel 0.40

amyloid pathology, but the mechanistic link between cholesterol dysregulation and enhanced

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Gap What molecular mechanisms drive T217 phosphorylation in MAPT R406W carriers without amyloid pathology? rel 0.40

amyloid levels, contradicting the established view that pT217 is primarily

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Gap What molecular mechanisms cause interneuron dysfunction to occur upstream of amyloid-β pathology in AD? rel 0.30

amyloid-β pathology, contradicting the traditional amyloid cascade hypothesis. Understanding

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Gap Why do p-tau231 and p-tau217 outperform other plasma biomarkers in detecting earliest amyloid pathology? rel 0.30

amyloid accumulation. The molecular basis for this differential performance compared

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Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

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