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30 results

Paper Genetic Insights into the Impact of Complement in Alzheimer's Disease. rel 1.30

complement in disease aetiology. Genetic variations in complement genes are widespread

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Paper Innate immunity and brain inflammation: the key role of complement. rel 1.10

Complement fragments (opsonins; C1q, C3b and iC3b) interact with complement

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Paper The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. rel 1.00

complement system is responsible for our defense against pathogens. The complement

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Paper Complement System and the Kidney: Its Role in Renal Diseases, Kidney Transplantation and Renal Cell Carcinoma. rel 0.90

complement system, immune cells, and mediators of inflammation provides an efficient

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Paper The complement system and human autoimmune diseases. rel 0.70

complement activation pathway (especially C1q, r, s, and C4) are the strongest

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Paper Synaptic pruning genes networks in Alzheimer's disease: correlations with neuropathology and cognitive decline. rel 0.60

complement system components (C1QA, C1QB, C1QC, C1S, C1R, C3), microglial

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Paper The classical complement cascade mediates CNS synapse elimination. rel 0.60

complement protein C1q or the downstream complement protein C3 exhibit

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Paper A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. rel 0.50

complement activation, in producing the necrotizing demyelination seen in the spinal

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Paper HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q. rel 0.50

complement deposition on synapses followed by microglial engulfment has been

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Gap How does complement activation contribute to cognitive deficits across different neurodegenerative diseases? rel 0.50

complement's role in cognitive deficits but doesn't explain

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Gap What is the molecular mechanism by which Nptx2 binding to C1q inhibits complement activation? rel 0.50

complement activity, but the specific molecular mechanism of how this

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Paper Free radicals upregulate complement expression in rabbit isolated heart. rel 0.40

complement activation can injure tissue. Our study determined whether free

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Paper Functional evaluation of factor H genetic and acquired abnormalities: application for atypical hemolytic uremic syndrome (aHUS). rel 0.40

complement pathway secondary to a not well-understood trigger event

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Paper Dual roles of complement in cerebral amyloid angiopathy: A two-compartment framework across the blood-brain barrier. rel 0.40

Complement is increasingly recognized as a context-dependent contributor to cerebral

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Paper 10.1038/nature18283 rel 0.40

complement cascade, a key component of innate immune pathogen defence

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Gap How does Alectinib, a kinase inhibitor, achieve high-affinity binding to complement protein C1q? rel 0.40

complement modulators. Gap type: unexplained_observation Source paper: Complement C1q-Targeted

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Paper The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody. rel 0.30

Complement deposition is present in all active white matter lesions

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Paper Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer's disease model. rel 0.30

complement-mediated microglial synaptic engulfment and attenuating synapse loss. These

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Paper Nonclinical Development of ANX005: A Humanized Anti-C1q Antibody for Treatment of Autoimmune and Neurodegenerative Diseases. rel 0.30

complement cascade. The safety and tolerability of ANX005 are currently

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Paper ApoE attenuates unresolvable inflammation by complex formation with activated C1q. rel 0.30

complement cascade (CCC), resulting in leukocyte infiltration of the choroid

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Paper Complement C1qB and C4 mRNAs responses to lesioning in rat brain. rel 0.30

complement components (C) in the adult rat brain and describe

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Paper Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice. rel 0.30

Complement-mediated synaptic pruning is essential in the developing and healthy

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Paper Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes. rel 0.30

complement, the pattern recognition molecules (PRMs) mannan-binding lectin (MBL) and ficolins

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Paper Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria. rel 0.30

complement inhibitors. Iptacopan, a first-in-class oral factor B inhibitor

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Paper Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy. rel 0.30

complement components. Gene regulatory network analysis identified TYROBP as the key regulatory

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Gap What downstream mechanisms link C3 inhibition to improved motor and visual function in NMO? rel 0.30

complement deposition and improves functional outcomes, but the specific molecular

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Gap How does CR2-Crry selectivity affect therapeutic efficacy versus systemic complement inhibition? rel 0.30

complement inhibition remains unclear. This knowledge gap is crucial for determining

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Gap What molecular mechanisms drive the female-specific complement-kininogen axis activation in trigeminal neuralgia? rel 0.30

complement components (C1QA, C1QC) and kininogen (KNG1) but provides no mechanistic

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Gap Which complement pathway components show the strongest correlation with PV interneuron loss in human AD progression? rel 0.30

complement proteins drive PV interneuron vulnerability versus general neuroinflammation. This

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Gap What mechanisms determine when complement-mediated synaptic pruning switches from beneficial to detrimental? rel 0.30

complement as both beneficial for developmental synaptic refinement and detrimental

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