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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 + Papers 1 + Wikis 1 ✓ Gaps 1 ✓ Colliders 0 + Debates 1 + Bounties 0 + Missions 1 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

19 results

Gap Ultrastructural and molecular drivers of dark microglia formation in neurodegeneration rel 0.60

microglia as a distinct ultrastructurally-defined microglia subset linked to pathological

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Gap [landscape-gap] Glia Diversity & Subclassification: Disease-associated microglia (DAM) vs homeostatic microglia states are debated; astrocyte functional subtypes are poorly mapped in humans. rel 0.50

microglia (DAM) vs homeostatic microglia states are debated; astrocyte functional

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Gap Sun 2023 microglia taxonomy reference unconfirmed after exhaustive search rel 0.50

microglia subtype taxonomy in human cortex could be confirmed. No PMID

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Gap Cross-cohort microglia subtype reconciliation: SEA-AD, ROSMAP, and Mathys 2023 rel 0.40

microglia subclusters generated from incompatible integration pipelines, differing Leiden resolutions

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Gap GEO accessions for Olah 2020 and Mathys 2023 microglia datasets unconfirmed by substrate search rel 0.30

microglia transcriptomics (candidate GSE127893, status unconfirmed) and (B) Mathys et al. 2023 Cell

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Gap Absence of direct cross-cohort MG-MOL coupling literature: SPP1+/GPNMB+ microglia and mature oligodendrocyte depletion in staged AD cortex rel 0.30

microglia co-occurrence with mature oligodendrocyte (MOL) depletion across Braak

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Gap Mechanisms of microglial senescence in ALS: causative vs consequential roles rel 0.30

microglia actively drive motor neuron loss, or do they accumulate

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Gap Retinal microglia S100A9-mediated NLRP3 inflammasome activation as a systemic inflammation link to neurodegeneration rel 0.30

microglia-derived S100A9 activating NLRP3 inflammasome in obese pig retina

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Gap What are the mechanisms by which microglial senescence contributes to ALS pathology? rel 0.20

microglia, (4) therapeutic targets to reverse or eliminate senescent microglia

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Gap Analyze the spectrum of microglial activation states (DAM, homeostatic, inflammatory) and their distinct roles in AD, PD, and ALS. Identify pharmacological targets for shifting microglia toward protec rel 0.20

roles in AD, PD, and ALS. Identify pharmacological targets for shifting microglia toward protective phenotypes.

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Gap Microglial senescence in Alzheimer and Parkinson disease progression rel 0.10

disease progression, and what therapeutic strategies could target senescent microglia?

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Gap Temporal ordering of MGnD expansion vs MOL depletion across Braak stages in human cortex rel 0.10

microglia (marked by SPP1, GPNMB, LPL, APOE) across the Braak

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Gap Microglial subtypes in neurodegeneration — friend vs foe rel 0.10

roles in AD, PD, and ALS. Identify pharmacological targets for shifting microglia toward protective phenotypes.

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Gap Do senescent oligodendrocyte precursors contribute to white matter degeneration through failed remyelination? rel 0.10

microglia and pericytes but didn't address whether OPC senescence

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Gap Mechanistic chain from microglial ISR activation to toxic lipid secretion and synapse loss rel 0.10

microglia and toxic lipid secretion causing synapse loss in AD models

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Gap TREM2-dependent microglial processing of alpha-synuclein fibrils via AEP truncation rel 0.10

microglia phagocytose alpha-synuclein fibrils via TREM2 and AEP cleaves

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Gap Where does TREM2 act in microglia? rel 0.10

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Gap Where does TREM2 act in microglia? rel 0.10

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Gap Does C1q function differ based on subcellular localization or binding partner identity? rel 0.10

microglia, or whether outcomes depend solely on binding partners. This

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