Details
- scope
- two-compartment rate circuit model
- claim_text
- Yang & Wang's dendritic disinhibitory circuit mechanism shows VIP→SST→pyramidal-dendrite disinhibition implements pathway-specific gating of top-down vs bottom-up inputs in cortical microcircuits.
- section_id
- section_13
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-13-conclusion
- source_kind
- review_finding
- source_path
- evidence/section_13_evidence_package.json
- study_system
- two-compartment rate circuit model
- section_title
- Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
- evidence_summary
- Two-compartment pyramidal cell model with SST→dendrite and VIP→SST disinhibition; pathway-specific gating of long-range inputs by VIP recruitment.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated_independent
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-13-conclusion
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- raw_fields
{ "n": null, "id": "cluster_11_finding_52", "doi": "10.1038/ncomms12815", "pmid": "27649374", "year": "2016", "claim": "Yang & Wang's dendritic disinhibitory circuit mechanism shows VIP→SST→pyramidal-dendrite disinhibition implements pathway-specific gating of top-down vs bottom-up inputs in cortical microcircuits.", "pmcid": "PMC5034308", "title": "A dendritic disinhibitory circuit mechanism for pathway-specific gating.", "authors": "Yang GR, Murray JD, Wang XJ.", "journal": "Nature communications", "cite_key": "Yang2016", "evidence": "Two-compartment pyramidal cell model with SST→dendrite and VIP→SST disinhibition; pathway-specific gating of long-range inputs by VIP recruitment.", "effect_size": null, "text_access": "fulltext", "study_system": "two-compartment rate circuit model", "_source_cluster": "cluster_11_computational_models", "replication_status": "replicated_independent", "_source_cluster_index": 51, "claim_source_sentence": "In this work, we developed a network model with thousands of pyramidal neurons and hundreds of interneurons for each (VIP, SOM and PV) type, and show that pathway-specific gating can be accomplished by the disinhibitory motif, even though the connectivity from SOM neurons to pyramidal neurons is dense: each SOM neuron on average targets >60% of neighbouring pyramidal neurons (<200 μm) 27 .", "replication_evidence_dois": [ "10.1016/j.neuron.2023.11.006", "10.1101/2025.05.13.653877", "10.1101/2024.09.30.615819", "10.1016/j.neuron.2018.03.037", "10.1162/netn_a_00427" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-1bdad28ffcad" ]
- source_span
In this work, we developed a network model with thousands of pyramidal neurons and hundreds of interneurons for each (VIP, SOM and PV) type, and show that pathway-specific gating can be accomplished by the disinhibitory motif, even though the connectivity from SOM neurons to pyramidal neurons is dense: each SOM neuron on average targets >60% of neighbouring pyramidal neurons (<200 μm) 27 .
- evidence_refs
[ { "ref": "paper:paper-1bdad28ffcad" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }