Details
- scope
- mouse hippocampus
- claim_text
- We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.
- section_id
- section_13
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- effect_size
- 120 mV
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-13-conclusion
- source_kind
- review_finding
- source_path
- evidence/section_13_evidence_package.json
- source_span
- We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.
- study_system
- mouse hippocampus
- section_title
- Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
- evidence_summary
- Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-13-conclusion
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
- raw_fields
{ "n": 13, "doi": "10.1126/science.abm8797", "year": "2022", "claim": "We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.", "title": null, "journal": "Science (New York, N.Y.)", "cite_key": "Kannan2022", "evidence": "Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types", "effect_size": "120 mV", "text_access": "fulltext", "study_system": "mouse hippocampus", "_source_cluster": "cluster_06_disinhibition_circuit", "replication_status": "replicated", "_source_cluster_index": 47, "claim_source_sentence": "We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.", "replication_evidence_dois": [ "10.1016/j.cell.2014.01.050", "10.7554/elife.14985", "10.1016/j.neuron.2018.03.037" ], "effect_size_source_sentence": "Ace-mNeon N81S G229Y and VARNAM Δ228W Δ229R G231I (henceforth, Ace-mNeon2 and VARNAM2, respectively) exhibited significantly improved fluorescence responses to depolarizing voltages compared to their predecessors in patch-clamp recordings from transfected cells ( ΔF / F for 120 mV step were (mean ± S.E.M.): −31.3 ± 0.7% for Ace-mNeon2 (n=13 cells) versus −13.9 ± 0.6% for Ace-mNeon (n=11 cells), P <0.0001, Mann-Whitney test; −22.9 ± 0.7% for VARNAM2 (n=13 cells) versus −14.1 ± 0.5% for VARNAM (n=8 cells), P <0.0001, Mann-Whitney test) ( Fig." }- source_refs
[ "paper:paper-5e76016e87f0" ]
- evidence_refs
[ { "ref": "paper:paper-5e76016e87f0" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }