Spike-timing dynamics of E, PV, and SST groups in a cortical model show that PV…

{
  "n": null,
  "id": "cluster_11_finding_32",
  "doi": "10.1016/j.celrep.2025.115954",
  "pmid": "40638386",
  "year": "2025",
  "claim": "Spike-timing dynamics of E, PV, and SST groups in a cortical model show that PV and SST interneurons differentially gate the synchronization of cortical spike times.",
  "pmcid": "PMC12370290",
  "title": "Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.",
  "authors": "Cammarata CM, Pei Y, Hu T, Shields BC, Lim SSX, Hawley T, Li JY, St Amand D, Brunel N, Tadross MR, Glickfeld LL.",
  "journal": "Cell reports",
  "cite_key": "Cammarata2025",
  "evidence": "Spike-time variance metrics under PV vs SST silencing isolate distinct gating roles.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "spiking neural network model of cortex with PV and SST",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 31,
  "claim_source_sentence": "Consistent with the literature, our model suggests that the effect of locomotion may occur through the modulation of VIP cells. 26 Of note, both SST cells and VIP cells are modulated by stimulus size: whereas SST cells prefer larger stimuli, VIP cells prefer smaller stimuli. 25 , 39 Thus, the size of the visual stimulus may further alter the interaction between SST and VIP cells and therefore the recruitment of SST cells to the ISN, particularly during aroused behavioral states.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-7fa8ffc9f200"
]

Consistent with the literature, our model suggests that the effect of locomotion may occur through the modulation of VIP cells. 26 Of note, both SST cells and VIP cells are modulated by stimulus size: whereas SST cells prefer larger stimuli, VIP cells prefer smaller stimuli. 25 , 39 Thus, the size of the visual stimulus may further alter the interaction between SST and VIP cells and therefore the recruitment of SST...

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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