A circuit model of mediodorsal thalamus and PFC, incorporating PV/SST/VIP inter…

{
  "n": null,
  "id": "cluster_11_finding_146",
  "doi": "10.1038/s41467-025-58011-1",
  "pmid": "40097445",
  "year": "2025",
  "claim": "A circuit model of mediodorsal thalamus and PFC, incorporating PV/SST/VIP interneurons, regulates task uncertainty and supports cognitive flexibility through disinhibitory gating.",
  "pmcid": "PMC11914509",
  "title": "Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility",
  "authors": "Zhang X, Mukherjee A, Halassa MM, Chen ZS.",
  "journal": "Nature Communications",
  "cite_key": "Zhang2025b",
  "evidence": "Authors developed a thalamo-cortical model of PFC interneuron-mediated cognitive flexibility consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.",
  "vip_role": "attention_topdown",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "thalamo-cortical model of PFC interneuron-mediated cognitive flexibility",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 145,
  "claim_source_sentence": "Our model reveals computational mechanisms and geometric interpretations of MD in regulating cue uncertainty and context switching to enable cognitive flexibility.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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