- claim_text
Thus, in addition to activity-dependent processes that contribute to the developmental trajectory of VIP cells, genetic programs engaged by Prox1 control the final differentiation of multipolar and bipolar subtypes.<b>SIGNIFICANCE STATEMENT</b> The transcription factor Prox1 generates functional diversification of cortical VIP interneuron subtypes in early postnatal life, thus expanding the inhibitory repertoire of the cortex.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.1021-21.2021",
"year": "2021",
"claim": "Thus, in addition to activity-dependent processes that contribute to the developmental trajectory of VIP cells, genetic programs engaged by Prox1 control the final differentiation of multipolar and bipolar subtypes.<b>SIGNIFICANCE STATEMENT</b> The transcription factor Prox1 generates functional diversification of cortical VIP interneuron subtypes in early postnatal life, thus expanding the inhibitory repertoire of the cortex.",
"title": null,
"journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience",
"cite_key": "Stachniak2021",
"evidence": "Postmitotic Prox1 Expression Controls the Final Specification of Cortical VIP Interneuron Subtypes",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse neocortex",
"_source_cluster": "cluster_06_disinhibition_circuit",
"snowball_origin": "forward_r2",
"replication_status": "replicated",
"_source_cluster_index": 104,
"claim_source_sentence": "Thus, in addition to activity-dependent processes that contribute to the developmental trajectory of VIP cells, genetic programs engaged by Prox1 control the final differentiation of multipolar and bipolar subtypes.<b>SIGNIFICANCE STATEMENT</b> The transcription factor Prox1 generates functional diversification of cortical VIP interneuron subtypes in early postnatal life, thus expanding the inhibitory repertoire of the cortex.",
"replication_evidence_dois": [
"10.1093/cercor/bhac343",
"10.1007/s00429-019-01883-z"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-b5b2bae45f13"
]
- source_span
Thus, in addition to activity-dependent processes that contribute to the developmental trajectory of VIP cells, genetic programs engaged by Prox1 control the final differentiation of multipolar and bipolar subtypes.<b>SIGNIFICANCE STATEMENT</b> The transcription factor Prox1 generates functional diversification of cortical VIP interneuron subtypes in early postnatal life, thus expanding the inhibitory repertoire of...
- evidence_refs
[
{
"ref": "paper:paper-b5b2bae45f13"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}