In a rate model with E, PV, and SOM populations, paradoxical PV responses to SO…

{
  "n": null,
  "id": "cluster_11_finding_04",
  "doi": "10.7554/elife.99808",
  "pmid": "40304591",
  "year": "2025",
  "claim": "In a rate model with E, PV, and SOM populations, paradoxical PV responses to SOM perturbations cannot disambiguate ISN from non-ISN regimes when SOM also targets E cells, complicating optogenetic tests of inhibitory stabilization.",
  "pmcid": "PMC12043317",
  "title": "Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.",
  "authors": "Bos H, Miehl C, Oswald AM, Doiron B.",
  "journal": "eLife",
  "cite_key": "Bos2025",
  "evidence": "Mathematical analysis combined with simulation shows paradoxical responses appear in both ISN and non-ISN regimes under realistic SOM→PV and SOM→E connectivity.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "three-population (E-PV-SOM) rate model with analytical stability analysis",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 3,
  "claim_source_sentence": "Thus the observation of paradoxical responses of PV neurons in response to suppression via SOM neurons cannot disclose whether the E neurons operate in the ISN or non-ISN regime if SOM neurons also suppress the activity of E neurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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