Highlights ► L4 SOM INs differ from those in other layers in both morphology an…

Highlights ► L4 SOM INs differ from those in other layers in both morphology and electrophysiology ► L4 SOM INs preferentially inhibit FS INs, while L2/3 SOM INs mainly inhibit PCs ► SOM INs disinhibit L4 via their inhibition of FS Ins ► This disinhibitory circuit is likely important for cortical sensory processing Xu et al. describe a disinhibitory microcircuit mediated by somatostatin-expressing GABAergic interneurons in the mouse somatosensory thalamorecipient layer 4 and suggest that this disinhibition represents an important circuit mechanism for cortical information processing.

{
  "n": null,
  "doi": "10.1016/j.neuron.2012.11.004",
  "year": "2013",
  "claim": "Highlights ► L4 SOM INs differ from those in other layers in both morphology and electrophysiology ► L4 SOM INs preferentially inhibit FS INs, while L2/3 SOM INs mainly inhibit PCs ► SOM INs disinhibit L4 via their inhibition of FS Ins ► This disinhibitory circuit is likely important for cortical sensory processing Xu et al. describe a disinhibitory microcircuit mediated by somatostatin-expressing GABAergic interneurons in the mouse somatosensory thalamorecipient layer 4 and suggest that this disinhibition represents an important circuit mechanism for cortical information processing.",
  "title": null,
  "journal": "Neuron",
  "cite_key": "Xu2013",
  "evidence": "Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4",
  "effect_size": "200-fold",
  "text_access": "fulltext",
  "study_system": "mammal S1",
  "_source_cluster": "cluster_06_disinhibition_circuit",
  "snowball_origin": "backward",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 76,
  "claim_source_sentence": "Highlights ► L4 SOM INs differ from those in other layers in both morphology and electrophysiology ► L4 SOM INs preferentially inhibit FS INs, while L2/3 SOM INs mainly inhibit PCs ► SOM INs disinhibit L4 via their inhibition of FS Ins ► This disinhibitory circuit is likely important for cortical sensory processing Xu et al. describe a disinhibitory microcircuit mediated by somatostatin-expressing GABAergic interneurons in the mouse somatosensory thalamorecipient layer 4 and suggest that this disinhibition represents an important circuit mechanism for cortical information processing.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The traces in the third row show the responses at threshold current injection, and the insets illustrate the first action potential from the corresponding traces, shown at the same vertical scale and at a 200-fold expanded horizontal scale."
}

[
  "paper:paper-92bf23cf430e"
]

Highlights ► L4 SOM INs differ from those in other layers in both morphology and electrophysiology ► L4 SOM INs preferentially inhibit FS INs, while L2/3 SOM INs mainly inhibit PCs ► SOM INs disinhibit L4 via their inhibition of FS Ins ► This disinhibitory circuit is likely important for cortical sensory processing Xu et al. describe a disinhibitory microcircuit mediated by somatostatin-expressing GABAergic interneu...

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    "ref": "paper:paper-92bf23cf430e"
  }
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    "Local review repositories are read-only inputs.",
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