- claim_text
A common finding between different cortical regions is that VIP+ IS cells suppress some local interneuron activity during complex behaviours, including visual processing 12 , 14 , 16 , locomotion 13 and reward-associated learning 17 , thus leading to network disinhibition.
- raw_fields
{
"n": null,
"doi": "10.1038/s41467-018-07162-5",
"year": "2018",
"claim": "A common finding between different cortical regions is that VIP+ IS cells suppress some local interneuron activity during complex behaviours, including visual processing 12 , 14 , 16 , locomotion 13 and reward-associated learning 17 , thus leading to network disinhibition.",
"title": null,
"journal": "Nature communications",
"cite_key": "Francavilla2018a",
"evidence": "Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mouse hippocampus",
"_source_cluster": "cluster_06_disinhibition_circuit",
"replication_status": "replicated",
"_source_cluster_index": 43,
"claim_source_sentence": "A common finding between different cortical regions is that VIP+ IS cells suppress some local interneuron activity during complex behaviours, including visual processing 12 , 14 , 16 , locomotion 13 and reward-associated learning 17 , thus leading to network disinhibition.",
"replication_evidence_dois": [
"10.1038/nn.3544",
"10.1126/science.1254126",
"10.1038/nn.4554"
],
"effect_size_source_sentence": "Interestingly, anatomical data point to the existence of long-range circuit elements that could account for cross-regional disinhibition between the hippocampus and functionally connected areas: CA1 SOM- or muscarinic receptor 2 (M2R)-expressing GABAergic cells innervate hippocampal inhibitory interneurons and can project to several cortical and sub-cortical areas, including the rhinal and retrosplenial cortices, subiculum (SUB) and medial septum (MS) 26 – 30 ."
}- source_refs
[
"paper:paper-c5dc6d520729"
]
- source_span
A common finding between different cortical regions is that VIP+ IS cells suppress some local interneuron activity during complex behaviours, including visual processing 12 , 14 , 16 , locomotion 13 and reward-associated learning 17 , thus leading to network disinhibition.
- evidence_refs
[
{
"ref": "paper:paper-c5dc6d520729"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}