Details

scope
biophysical CA1 model
claim_text
Biophysical hippocampal model with cell-type-specific contributions of PV, SST, VIP and CCK interneurons reproduces theta-gamma cross-frequency coupling and reveals VIP disinhibitory contributions to gamma envelope modulation.
section_id
section_12
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-12-computational-models
source_kind
review_finding
source_path
evidence/section_12_evidence_package.json
source_span
Common principles in functional organization of VIP/calretinin cell-driven disinhibitory circuits across cortical areas.
study_system
biophysical CA1 model
section_title
Computational Models of VIP Circuit Function
evidence_summary
Multi-compartment Hodgkin-Huxley CA1 model with multiple interneuron types; ablation analysis quantifies VIP contribution to theta-gamma coupling.
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
replicated_independent
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-12-computational-models
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": null,
  "id": "cluster_11_finding_46",
  "doi": "10.1162/netn_a_00427",
  "pmid": "40161984",
  "year": "2025",
  "claim": "Biophysical hippocampal model with cell-type-specific contributions of PV, SST, VIP and CCK interneurons reproduces theta-gamma cross-frequency coupling and reveals VIP disinhibitory contributions to gamma envelope modulation.",
  "pmcid": "PMC11949547",
  "title": "Cell-type-specific contributions to theta-gamma coupled rhythms in the hippocampus.",
  "authors": "Sengupta S, Talidou A, Lefebvre J, Skinner FK.",
  "journal": "Network neuroscience (Cambridge, Mass.)",
  "cite_key": "Sengupta2025",
  "evidence": "Multi-compartment Hodgkin-Huxley CA1 model with multiple interneuron types; ablation analysis quantifies VIP contribution to theta-gamma coupling.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "biophysical CA1 model",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 45,
  "claim_source_sentence": "Common principles in functional organization of VIP/calretinin cell-driven disinhibitory circuits across cortical areas.",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2023.11.006",
    "10.1101/2025.05.13.653877",
    "10.1101/2024.09.30.615819",
    "10.1016/j.neuron.2018.03.037",
    "10.1523/eneuro.0235-21.2021"
  ],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-7a933b7da09d",
  "paper:paper-d2eb243f7272"
]
evidence_refs
[
  {
    "ref": "paper:paper-7a933b7da09d"
  },
  {
    "ref": "paper:paper-d2eb243f7272"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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