Hippocampal CA1 input drives a spiking model of mPFC interneurons in which VIP…

{
  "n": null,
  "id": "cluster_11_finding_122",
  "doi": "10.1101/2025.07.21.665987",
  "pmid": "",
  "year": "2025",
  "claim": "Hippocampal CA1 input drives a spiking model of mPFC interneurons in which VIP and SST plasticity sets context-dependent disinhibition of pyramidal cells supporting memory-guided behavior.",
  "pmcid": "",
  "title": "Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory",
  "authors": "Silverstein SE, Clarity TT, Deshpande MS, Vaughan E, Novik S, Yarur HE, Zhang S, Tsai VS, Ye R, Mikofsky RM, Hsiang M, Bauman A, Loewinger G, Pereira F, Morales M, Sohal VS, Tejeda HA, Gordon JA, Kupferschmidt DA.",
  "journal": "bioRxiv",
  "cite_key": "Silverstein2025",
  "evidence": "Authors developed a spiking network model of mPFC microcircuit driven by hippocampal CA1 inputs consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.",
  "vip_role": "context_modulation",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "spiking network model of mPFC microcircuit driven by hippocampal CA1 inputs",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 121,
  "claim_source_sentence": "Repeated vHPC input stimulation persistently depressed activity in vasoactive intestinal peptide (VIP)-expressing interneurons and potentiated activity in somatostatin-expressing interneurons. <i>Ex vivo</i> whole-cell electrophysiology and computational modeling revealed that these divergent effects likely arise from a primary weakening of monosynaptic vHPC input onto VIP interneurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-36d9647d5758"
]

Repeated vHPC input stimulation persistently depressed activity in vasoactive intestinal peptide (VIP)-expressing interneurons and potentiated activity in somatostatin-expressing interneurons. <i>Ex vivo</i> whole-cell electrophysiology and computational modeling revealed that these divergent effects likely arise from a primary weakening of monosynaptic vHPC input onto VIP interneurons.

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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