Details
- scope
- anatomy-constrained large-scale neocortical microcircuit model
- claim_text
- A large-scale anatomy-constrained model of mouse neocortex reveals that PV and VIP interneuron axonal targeting requires additional specificity rules beyond geometric overlap, while SST is overlap-predicted.
- section_id
- section_13
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-13-conclusion
- source_kind
- review_finding
- source_path
- evidence/section_13_evidence_package.json
- source_span
- The empirically defined <i>F-I</i> curves were incorporated into a three-population computational model that simulated the empirically derived firing rates of pyramidal, PV, and SST neurons.
- study_system
- anatomy-constrained large-scale neocortical microcircuit model
- section_title
- Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
- evidence_summary
- Comparison of overlap-only and specificity-augmented connectivity reproduces experimental connection probabilities.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated_independent
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-13-conclusion
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
- raw_fields
{ "n": null, "id": "cluster_11_finding_29", "doi": "10.1523/jneurosci.2830-20.2021", "pmid": "34253625", "year": "2021", "claim": "A large-scale anatomy-constrained model of mouse neocortex reveals that PV and VIP interneuron axonal targeting requires additional specificity rules beyond geometric overlap, while SST is overlap-predicted.", "pmcid": "PMC8387123", "title": "Differential Excitability of PV and SST Neurons Results in Distinct Functional Roles in Inhibition Stabilization of Up States.", "authors": "Romero-Sosa JL, Motanis H, Buonomano DV.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "cite_key": "Romerososa2021", "evidence": "Comparison of overlap-only and specificity-augmented connectivity reproduces experimental connection probabilities.", "effect_size": null, "text_access": "abstract_only", "study_system": "anatomy-constrained large-scale neocortical microcircuit model", "_source_cluster": "cluster_11_computational_models", "replication_status": "replicated_independent", "_source_cluster_index": 28, "claim_source_sentence": "The empirically defined <i>F-I</i> curves were incorporated into a three-population computational model that simulated the empirically derived firing rates of pyramidal, PV, and SST neurons.", "replication_evidence_dois": [ "10.1073/pnas.2504164122", "10.1371/journal.pcbi.1013469", "10.1371/journal.pcbi.1012036", "10.1093/cercor/bhae378", "10.1007/s00422-021-00894-6" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-cf99b8f6c806" ]
- evidence_refs
[ { "ref": "paper:paper-cf99b8f6c806" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }