Details
- scope
- mean-field whole-cortex model + EEG
- claim_text
- Mean-field whole-cortex model with PV/SST/VIP interneurons explains propofol-induced loss of consciousness as failure of feedback predictive routing through VIP-disinhibitory gating.
- section_id
- section_12
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-12-computational-models
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- This led to a disinhibition of gamma/spiking, consistent with the predictive routing model.
- study_system
- mean-field whole-cortex model + EEG
- section_title
- Computational Models of VIP Circuit Function
- evidence_summary
- Coupled cortical regions modeled with cell-class-specific GABA-A; anesthesia simulated via potentiation of GABA shifts predictive flow.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated_independent
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-12-computational-models
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
- raw_fields
{ "n": null, "id": "cluster_11_finding_87", "doi": "10.1073/pnas.2315160121", "pmid": "39374396", "year": "2024", "claim": "Mean-field whole-cortex model with PV/SST/VIP interneurons explains propofol-induced loss of consciousness as failure of feedback predictive routing through VIP-disinhibitory gating.", "pmcid": "PMC11494327", "title": "Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.", "authors": "Xiong YS, Donoghue JA, Lundqvist M, Mahnke M, Major AJ, Brown EN, Miller EK, Bastos AM.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "cite_key": "Xiong2024", "evidence": "Coupled cortical regions modeled with cell-class-specific GABA-A; anesthesia simulated via potentiation of GABA shifts predictive flow.", "effect_size": null, "text_access": "fulltext", "study_system": "mean-field whole-cortex model + EEG", "_source_cluster": "cluster_11_computational_models", "replication_status": "replicated_independent", "_source_cluster_index": 86, "claim_source_sentence": "This led to a disinhibition of gamma/spiking, consistent with the predictive routing model.", "replication_evidence_dois": [ "10.7554/elife.55130", "10.1523/jneurosci.1369-21.2021", "10.1038/s41598-017-01830-0", "10.1371/journal.pcbi.1013306", "10.1016/j.neuron.2021.11.016" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-ef4c763cc63c" ]
- evidence_refs
[ { "ref": "paper:paper-ef4c763cc63c" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }