VIP-Cre cell population is entirely contained within the HTR3A-GFP population (…

Details

scope: mouse V1, VIP-Cre × Ai14 with HTR3A-GFP, PV-Cre, Sst-Cre crosses
section_id: section_05
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
effect_size: VIP-Cre overlap: HTR3A-GFP 100%; PV-Cre 0%; Sst-Cre 0%
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-05-electrophysiology
source_kind: review_finding
source_path: evidence/section_05_evidence_package.json
source_span: Virtually all VIP-Cre cells (visualized by tdTomato expression) also expressed green fluorescent protein (GFP) (100%; Fig.
study_system: mouse V1, VIP-Cre × Ai14 with HTR3A-GFP, PV-Cre, Sst-Cre crosses
section_title: Intrinsic Electrophysiology
evidence_summary: VIP-Cre×Ai14 cross with HTR3A-GFP reporter mice; quantitative co-localization across L2/3 and L5
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replicated
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-05-electrophysiology
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (5)

claim_text

VIP-Cre cell population is entirely contained within the HTR3A-GFP population (100% overlap of VIP-Cre/tdTomato with HTR3A-GFP) and shows zero overlap with PV-Cre or Sst-Cre populations, validating VIP-Cre as a clean genetic handle that selects a subset of the broader 5HT3aR class.

raw_fields

{
  "n": null,
  "doi": "10.1038/nn.3446",
  "claim": "VIP-Cre cell population is entirely contained within the HTR3A-GFP population (100% overlap of VIP-Cre/tdTomato with HTR3A-GFP) and shows zero overlap with PV-Cre or Sst-Cre populations, validating VIP-Cre as a clean genetic handle that selects a subset of the broader 5HT3aR class.",
  "title": null,
  "cite_key": "Pfeffer2013",
  "evidence": "VIP-Cre×Ai14 cross with HTR3A-GFP reporter mice; quantitative co-localization across L2/3 and L5",
  "effect_size": "VIP-Cre overlap: HTR3A-GFP 100%; PV-Cre 0%; Sst-Cre 0%",
  "text_access": "fulltext",
  "study_system": "mouse V1, VIP-Cre × Ai14 with HTR3A-GFP, PV-Cre, Sst-Cre crosses",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 37,
  "claim_source_sentence": "Virtually all VIP-Cre cells (visualized by tdTomato expression) also expressed green fluorescent protein (GFP) (100%; Fig.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.1869-10.2010"
  ],
  "effect_size_source_sentence": "Thus, the VIP-Cre population is a sub-population of and is entirely comprised in the HTR3A-GFP population."
}

source_refs

[
  "paper:paper-1659c2dc5d60"
]

evidence_refs

[
  {
    "ref": "paper:paper-1659c2dc5d60"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

VIP-Cre cell population is entirely contained within the HTR3A-GFP population (…

Details

Replication

Discussion