- claim_text
VIP→Sst inhibition has the largest VIP output amplitude in L2/3 mouse V1 (INC_VIP→Sst = 0.42±0.14 pC), about 7× larger than VIP→pyramid inhibition (INC_VIP→Pyr = 0.06±0.02 pC), establishing SST cells — not pyramidal neurons — as the principal direct target of VIP synaptic output and quantifying the canonical VIP→SST→pyramid disinhibitory motif.
- raw_fields
{
"n": 11,
"doi": "10.1038/nn.3446",
"claim": "VIP→Sst inhibition has the largest VIP output amplitude in L2/3 mouse V1 (INC_VIP→Sst = 0.42±0.14 pC), about 7× larger than VIP→pyramid inhibition (INC_VIP→Pyr = 0.06±0.02 pC), establishing SST cells — not pyramidal neurons — as the principal direct target of VIP synaptic output and quantifying the canonical VIP→SST→pyramid disinhibitory motif.",
"title": null,
"cite_key": "Pfeffer2013",
"evidence": "paired patch clamp + ChR2 in mouse V1 L2/3 (Pfeffer et al 2013)",
"effect_size": "INC VIP→Sst = 0.42±0.14 pC; VIP→Pyr = 0.06±0.02 pC; n=11 paired",
"text_access": "fulltext",
"study_system": "mouse V1 L2/3; paired ChR2-IPSC",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 82,
"claim_source_sentence": "Inhibition mediated by VIP cells onto Sst-expressing cells was much larger than onto the simultaneously recorded pyramids.",
"replication_evidence_dois": [
"10.1038/ncomms13664"
],
"effect_size_source_sentence": "average IPSQ Sst 4.6±1.5pC; average IPSQ Pyr 0.6±0.2pC; n=11; INC VIP→Sst =0.42±0.14pC as compared to the much smaller INC VIP→pyramid =0.06±0.02pC."
}- source_refs
[
"paper:paper-1659c2dc5d60"
]
- evidence_refs
[
{
"ref": "paper:paper-1659c2dc5d60"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}