VIP-Cre, Pvalb-Cre, and Sst-Cre populations are largely non-overlapping in mous…

VIP-Cre, Pvalb-Cre, and Sst-Cre populations are largely non-overlapping in mouse V1 (max overlap 6% PV-SST and 1% PV-VIP), comprising 36% ± 0.5%, 30% ± 1.5%, and 17% ± 1% respectively of the GAD67-GFP interneuron population — supporting their use as orthogonal molecular handles for class-specific intrinsic-electrophysiology comparisons.

{
  "n": null,
  "doi": "10.1038/nn.3446",
  "claim": "VIP-Cre, Pvalb-Cre, and Sst-Cre populations are largely non-overlapping in mouse V1 (max overlap 6% PV-SST and 1% PV-VIP), comprising 36% ± 0.5%, 30% ± 1.5%, and 17% ± 1% respectively of the GAD67-GFP interneuron population — supporting their use as orthogonal molecular handles for class-specific intrinsic-electrophysiology comparisons.",
  "title": null,
  "cite_key": "Pfeffer2013",
  "evidence": "scRNA + IHC (Pfeffer 2013)",
  "effect_size": "PV 36%, SST 30%, VIP 17% of GAD67+; max overlap PV/SST 6%, PV/VIP 1%",
  "text_access": "fulltext",
  "study_system": "mouse V1; Cre + IHC",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 84,
  "claim_source_sentence": "Pvalb-Cre, Sst-Cre and VIP-Cre cells made up 36%±0.5, 30%±1.5 and 17%±1 of the GAD67-GFP population.",
  "replication_evidence_dois": [
    "10.1093/cercor/bhv202",
    "10.1002/dneu.20853"
  ],
  "effect_size_source_sentence": "These data indicate that the overlap between the Pvalb-Cre and the Sst- and VIP-Cre populations is maximally 6% and 1%, respectively."
}

[
  "paper:paper-1659c2dc5d60"
]

[
  {
    "ref": "paper:paper-1659c2dc5d60"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}