A biophysical PV interneuron model with dendritic NMDA receptors enables strong…

{
  "n": null,
  "id": "cluster_11_finding_153",
  "doi": "10.7554/elife.49872",
  "pmid": "31657720",
  "year": "2019",
  "claim": "A biophysical PV interneuron model with dendritic NMDA receptors enables strong and stable network oscillations, refining computational accounts of PV–SST–VIP interactions.",
  "pmcid": "PMC6839945",
  "title": "Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies",
  "authors": "Cornford JH, Mercier MS, Leite M, Magloire V, Häusser M, Kullmann DM.",
  "journal": "eLife",
  "cite_key": "Cornford2019",
  "evidence": "Authors developed a biophysical PV interneuron model with dendritic NMDA receptors and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.",
  "vip_role": "oscillations",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "biophysical PV interneuron model with dendritic NMDA receptors",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 152,
  "claim_source_sentence": "Furthermore, by incorporating NMDARs at feedback connections onto PV+ cells in spiking networks, we show that these receptors enable cooperative recruitment of PV+ interneurons, strengthening and stabilising principal cell assemblies.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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