Single-cell axon reconstruction of mouse ventral tegmental area neurons reveals…

Single-cell axon reconstruction of mouse ventral tegmental area neurons reveals two morphological classes — forebrain-projecting (FPN) and forebrain+brainstem-projecting (F+BSPN) — and four subtypes among FPNs based on projection target, including a mesostriatal subtype targeting only the caudate-putamen.

{
  "n": 30,
  "doi": "10.3389/fnana.2015.00059",
  "claim": "Single-cell axon reconstruction of mouse ventral tegmental area neurons reveals two morphological classes — forebrain-projecting (FPN) and forebrain+brainstem-projecting (F+BSPN) — and four subtypes among FPNs based on projection target, including a mesostriatal subtype targeting only the caudate-putamen.",
  "cite_key": "Aransay2015",
  "evidence": "Single-cell Sindbis-pal-eGFP transfection of VTA neurons (n=30) with serial-section axon reconstruction and stereological measurement.",
  "effect_size": "30 single VTA neurons reconstructed; 4 FPN subtypes (mesocorticolimbic, mesocortical, mesolimbic, mesostriatal)",
  "text_access": "abstract_only",
  "study_system": "mouse (single-neuron Sindbis labeling + serial reconstruction)",
  "source_cluster_id": "cluster_03",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We observed two main, markedly different VTA cell morphologies: neurons with a single main axon targeting only forebrain structures (FPN cells), and neurons with multibranched axons targeting both the forebrain and the brainstem (F + BSPN cells).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "(4) \"Mesostriatal\" FPN targeting only the caudateputamen."
}

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  "paper:paper-353c1a63d3ff"
]

We observed two main, markedly different VTA cell morphologies: neurons with a single main axon targeting only forebrain structures (FPN cells), and neurons with multibranched axons targeting both the forebrain and the brainstem (F + BSPN cells).

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