Details
- scope
- biophysical CA1 IS3 single-cell model
- claim_text
- A multi-compartment model of CA1 IS3 (VIP+/CR+) interneurons reveals that VIP-IS3 cells preferentially fire to disinhibit OLM cells during specific theta phases, supporting hippocampal disinhibitory motif.
- section_id
- section_13
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-13-conclusion
- source_kind
- review_finding
- source_path
- evidence/section_13_evidence_package.json
- study_system
- biophysical CA1 IS3 single-cell model
- section_title
- Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
- evidence_summary
- Detailed Hodgkin-Huxley CA1 IS3 cell model fit to electrophysiology, simulated with realistic synaptic inputs; predicts in vivo firing patterns.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated_independent
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-13-conclusion
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- raw_fields
{ "n": null, "id": "cluster_11_finding_49", "doi": "10.1371/journal.pone.0209429", "pmid": "30620732", "year": "2019", "claim": "A multi-compartment model of CA1 IS3 (VIP+/CR+) interneurons reveals that VIP-IS3 cells preferentially fire to disinhibit OLM cells during specific theta phases, supporting hippocampal disinhibitory motif.", "pmcid": "PMC6324795", "title": "Using computational models to predict in vivo synaptic inputs to interneuron specific 3 (IS3) cells of CA1 hippocampus that also allow their recruitment during rhythmic states.", "authors": "Guet-McCreight A, Skinner FK.", "journal": "PloS one", "cite_key": "Guetmccreight2019", "evidence": "Detailed Hodgkin-Huxley CA1 IS3 cell model fit to electrophysiology, simulated with realistic synaptic inputs; predicts in vivo firing patterns.", "effect_size": null, "text_access": "fulltext", "study_system": "biophysical CA1 IS3 single-cell model", "_source_cluster": "cluster_11_computational_models", "replication_status": "replicated_independent", "_source_cluster_index": 48, "claim_source_sentence": "Science . 2014 ; 345 ( 6197 ): 660 – 665 . 10.1126/science.1254126 25104383 PMC5776147 31 Karnani MM , Jackson J , Ayzenshtat I , Sichani AH , Manoocheri K , Kim S , et al Opening Holes in the Blanket of Inhibition: Localized Lateral Disinhibition by VIP Interneurons .", "replication_evidence_dois": [ "10.1016/j.neuron.2023.11.006", "10.1101/2025.05.13.653877", "10.1101/2024.09.30.615819", "10.1016/j.neuron.2018.03.037", "10.1162/netn_a_00427" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-179aeabaffe8" ]
- source_span
Science . 2014 ; 345 ( 6197 ): 660 – 665 . 10.1126/science.1254126 25104383 PMC5776147 31 Karnani MM , Jackson J , Ayzenshtat I , Sichani AH , Manoocheri K , Kim S , et al Opening Holes in the Blanket of Inhibition: Localized Lateral Disinhibition by VIP Interneurons .
- evidence_refs
[ { "ref": "paper:paper-179aeabaffe8" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }