Since PV interneurons do not express the requisite β2 subunit to form a functio…

{
  "n": null,
  "doi": "10.1038/nm.4274",
  "year": "2017",
  "claim": "Since PV interneurons do not express the requisite β2 subunit to form a functional α5-containing nAChR, these results may be due to the expression of the α5 subunit in either VIP or SOM interneurons.",
  "title": null,
  "journal": "Nature medicine",
  "cite_key": "Koukouli2017",
  "evidence": "Nicotine reverses hypofrontality in animal models of addiction and schizophrenia",
  "effect_size": "2.9% of",
  "text_access": "fulltext",
  "first_author": "Koukouli",
  "study_system": "mouse PFC/frontal cortex",
  "_source_cluster": "cluster_06_disinhibition_circuit",
  "author_list_short": "Koukouli, Rooy, Tziotis",
  "replication_status": "replicated",
  "_source_cluster_index": 24,
  "claim_source_sentence": "Since PV interneurons do not express the requisite β2 subunit to form a functional α5-containing nAChR, these results may be due to the expression of the α5 subunit in either VIP or SOM interneurons.",
  "replication_evidence_dois": [
    "10.1038/nn.4002",
    "10.1038/s41467-019-13244-9"
  ],
  "effect_size_source_sentence": "Wild-type (WT) mice exhibited a clear preference for a novel social partner, spending 69.6 ± 2.9% of their time engaged in social interaction, while α5SNP littermates showed no preference between the social partner and an inanimate object (44.1 ± 5.3%) ( Fig."
}

[
  "paper:paper-9f4aa2a403bd"
]

[
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  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}