Feature-selective inhibition through VIP-mediated disinhibition of SST enables…

{
  "n": null,
  "id": "cluster_11_finding_15",
  "doi": "10.1038/s41598-025-28227-8",
  "pmid": "41326499",
  "year": "2025",
  "claim": "Feature-selective inhibition through VIP-mediated disinhibition of SST enables expectation suppression in a cortical microcircuit model, reconciling top-down predictions with bottom-up sensory drive.",
  "pmcid": "PMC12738544",
  "title": "Feature selective inhibitory mechanisms enable expectation suppression in cortical microcircuits.",
  "authors": "Huang Y.",
  "journal": "Scientific reports",
  "cite_key": "Huang2025a",
  "evidence": "Models compare with empirical mismatch responses; expectation suppression requires VIP→SST disinhibition selective to predicted features.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "spiking/rate cortical microcircuit model of V1 with three interneuron types",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 14,
  "claim_source_sentence": "In our model, to capture the complementary inhibitory and disinhibitory roles of SOM and VIP neurons under expected and unexpected conditions, we assumed that SOM neurons primarily receive top-down predictive inputs, whereas VIP neurons predominantly receive bottom-up sensory inputs.",
  "replication_evidence_dois": [
    "10.1073/pnas.2504164122",
    "10.1371/journal.pcbi.1013469",
    "10.1371/journal.pcbi.1012036",
    "10.1093/cercor/bhae378",
    "10.1007/s00422-021-00894-6"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:paper-a93a660fe891"
]

In our model, to capture the complementary inhibitory and disinhibitory roles of SOM and VIP neurons under expected and unexpected conditions, we assumed that SOM neurons primarily receive top-down predictive inputs, whereas VIP neurons predominantly receive bottom-up sensory inputs.

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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