Postmitotic deletion of Prox1 in early postnatal VIP interneurons differentiall…

Postmitotic deletion of Prox1 in early postnatal VIP interneurons differentially impairs excitatory input dynamics onto bipolar versus multipolar VIP subtypes, and reduces Elfn1 function selectively in multipolar VIP cells, demonstrating that Prox1 acts as a postmitotic specifier of VIP subtype diversification.

{
  "n": null,
  "doi": "10.1523/jneurosci.1021-21.2021",
  "claim": "Postmitotic deletion of Prox1 in early postnatal VIP interneurons differentially impairs excitatory input dynamics onto bipolar versus multipolar VIP subtypes, and reduces Elfn1 function selectively in multipolar VIP cells, demonstrating that Prox1 acts as a postmitotic specifier of VIP subtype diversification.",
  "title": null,
  "cite_key": "Stachniak2021",
  "evidence": "Body, Results/Discussion: VIPCre × conditional Prox1 allele to remove Prox1 during first postnatal week; synaptic in vitro electrophysiology, pharmacology, and genetic experiments in male and female mice.",
  "effect_size": "Differential effect: Prox1 cKO reduces Elfn1-dependent short-term plasticity in multipolar but not bipolar VIP cells",
  "text_access": "fulltext",
  "study_system": "mouse cortex (postnatal), VIPCre conditional Prox1 KO, in vitro slice electrophysiology",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replicated",
  "_source_cluster_index": 2,
  "claim_source_sentence": "Thus, in addition to activity-dependent processes that contribute to the developmental trajectory of VIP cells, genetic programs engaged by Prox1 control the final differentiation of multipolar and bipolar subtypes.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.1164-15.2015"
  ],
  "effect_size_source_sentence": "Further genetic, pharmacological, and electrophysiological experiments demonstrate that removing Prox1 reduces Elfn1 function in VIP multipolar but not in bipolar cells."
}

[
  "paper:paper-b5b2bae45f13"
]

[
  {
    "ref": "paper:paper-b5b2bae45f13"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}