Cell-type-specific E→E motifs in mouse: IT, PT, and CT pyramidal projection classes
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1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference. That description is silent on cellular identity beyond geometry. {ref}`s... -
2Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference. That description is silent on cellular identity beyond geometry. {ref}`s... -
3Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference. That description is silent on cellular identity beyond geometry. {ref}`s... -
4Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference. That description is silent on cellular identity beyond geometry. {ref}`s... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference. That description is silent on cellular identity beyond geometry. {ref}`s... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1. That description is silent on cellular identity beyond geometry. {ref}`s... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3. That description is silent on cellular identity beyond geometry. {ref}`s... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5. That description is silent on cellular identity beyond geometry. {ref}`s... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7. That description is silent on cellular identity beyond geometry. {ref}`s... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9. That description is silent on cellular identity beyond geometry. {ref}`s... -
2Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1. That description is silent on cellular identity beyond geometry. {ref}`s... -
2Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3. That description is silent on cellular identity beyond geometry. {ref}`s... -
2Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5. That description is silent on cellular identity beyond geometry. {ref}`s... -
2Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7. That description is silent on cellular identity beyond geometry. {ref}`s... -
2Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
3Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 3Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
3Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 3Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
3Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 3Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
3Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6 The IT/PT/CT vocabulary used throughout this section, introduced in{ref}sec-anatomy-primer, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. 3Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7 defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary... -
3Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 3Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9. The Allen Mouse Brain Connectivity Atlas —... -
4Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 4Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1. The Allen Mouse Brain Connectivity Atlas —... -
4Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 4Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3. The Allen Mouse Brain Connectivity Atlas —... -
4Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 4Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5. The Allen Mouse Brain Connectivity Atlas —... -
4Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 4Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7. The Allen Mouse Brain Connectivity Atlas —... -
4Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 4Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7. The Allen Mouse Brain Connectivity Atlas —... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8 The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9. The Allen Mouse Brain Connectivity Atlas —... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0 Mouse-cortex transcriptomic taxonomies — counts at comparable levels. Successive mouse-cortex single-cell transcriptomic taxonomies report type counts at heterogeneous scopes and grains. The table restricts to cortical scope and lists the subclass-level partition (where reported) alongside finer-grained type counts and total cells profiled, so that the IT/PT/CT subclass labels can be tracked across taxonomies on... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1 Mouse-cortex transcriptomic taxonomies — counts at comparable levels. Successive mouse-cortex single-cell transcriptomic taxonomies report type counts at heterogeneous scopes and grains. The table restricts to cortical scope and lists the subclass-level partition (where reported) alongside finer-grained type counts and total cells profiled, so that the IT/PT/CT subclass labels can be tracked across taxonomies on... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2 Mouse-cortex transcriptomic taxonomies — counts at comparable levels. Successive mouse-cortex single-cell transcriptomic taxonomies report type counts at heterogeneous scopes and grains. The table restricts to cortical scope and lists the subclass-level partition (where reported) alongside finer-grained type counts and total cells profiled, so that the IT/PT/CT subclass labels can be tracked across taxonomies on... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3 Mouse-cortex transcriptomic taxonomies — counts at comparable levels. Successive mouse-cortex single-cell transcriptomic taxonomies report type counts at heterogeneous scopes and grains. The table restricts to cortical scope and lists the subclass-level partition (where reported) alongside finer-grained type counts and total cells profiled, so that the IT/PT/CT subclass labels can be tracked across taxonomies on... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4 Mouse-cortex transcriptomic taxonomies — counts at comparable levels. Successive mouse-cortex single-cell transcriptomic taxonomies report type counts at heterogeneous scopes and grains. The table restricts to cortical scope and lists the subclass-level partition (where reported) alongside finer-grained type counts and total cells profiled, so that the IT/PT/CT subclass labels can be tracked across taxonomies on... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5 Mouse-cortex transcriptomic taxonomies — counts at comparable levels. Successive mouse-cortex single-cell transcriptomic taxonomies report type counts at heterogeneous scopes and grains. The table restricts to cortical scope and lists the subclass-level partition (where reported) alongside finer-grained type counts and total cells profiled, so that the IT/PT/CT subclass labels can be tracked across taxonomies on... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6 The two largest mouse-cortex taxonomies adopt opposite framings of the same glutamatergic diversity. 5Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7 emphasised that almost all GABAergic types are shared between VISp and ALM while most glutamatergic types are area-specific, supporting a discrete taxonomic description in which higher-order area identity reshapes which excitatory types are populated. 5Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference8 profiled the whole isocortex at much gr... -
5Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference9 The two largest mouse-cortex taxonomies adopt opposite framings of the same glutamatergic diversity. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference0 emphasised that almost all GABAergic types are shared between VISp and ALM while most glutamatergic types are area-specific, supporting a discrete taxonomic description in which higher-order area identity reshapes which excitatory types are populated. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference1 profiled the whole isocortex at much gr... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference2 The two largest mouse-cortex taxonomies adopt opposite framings of the same glutamatergic diversity. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference3 emphasised that almost all GABAergic types are shared between VISp and ALM while most glutamatergic types are area-specific, supporting a discrete taxonomic description in which higher-order area identity reshapes which excitatory types are populated. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference4 profiled the whole isocortex at much gr... -
1Citation{ref}
sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference5 The two largest mouse-cortex taxonomies adopt opposite framings of the same glutamatergic diversity. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference6 emphasised that almost all GABAergic types are shared between VISp and ALM while most glutamatergic types are area-specific, supporting a discrete taxonomic description in which higher-order area identity reshapes which excitatory types are populated. 1Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference, 2Citation{ref}sec-connectomic-miconsestablished that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...content/07_celltype_motifs.md:line 5Open reference7 profiled the whole isocortex at much gr... -
... 153 additional anchors in refs_json
References
- [TheMICrONSConsortium2025] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Ding2023a] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Tasic2018] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Yao2021a] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Scala2021] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Sorensen2023] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Brown2009] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Kiritani2012] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Morishima2011] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Anderson2010] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Cadwell2016] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Chen2019a] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Yao2024] “{ref}`sec-connectomic-micons` established that millimetre-scale electron-microscopy (EM) reconstructions of mouse visual cortex resolve every excitatory–excitatory contact in a contiguous volume, and that the resulting wiring is sparse and structured by functional similarity rather than random within layers [TheMICrONSConsortium2025,Ding2023a]. That description is silent on cellular identity beyond geometry. {ref}`s...”
- [Tasic2016] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [Yao2023b] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [Yao2021b] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [BRAINInitiativeCellCensusNetworkBICCN2021] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [Booeshaghi2021] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [Bakken2018] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [Zhang2021c] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [Bakken2021] “The IT/PT/CT vocabulary used throughout this section, introduced in {ref}`sec-anatomy-primer`, comes from a sequence of mouse-cortex single-cell transcriptomic taxonomies whose total type count has grown by roughly two orders of magnitude in a decade while the subclass labels have stayed largely fixed. [Tasic2016] defined 19 glutamatergic and 23 GABAergic transcriptomic types from 1,679 cells in adult mouse primary...”
- [Yamawaki2015] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Harris2019] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Hooks2013] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Oh2014] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Cadwell2020] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Scala2019] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Nandi2022] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Condylis2022] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Gao2025] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
- [Klingler2021] “The most consistent intersection of these taxonomies with circuit anatomy is at the subclass level: each is recovered by a small set of well-validated Cre driver lines (Rbp4, Tlx3, Sim1, Fezf2, Ntsr1, Cux2) that the projection-class connectivity literature relies on for cell-type-specific labelling and optogenetic targeting [Anderson2010,Yamawaki2015,Harris2019,Hooks2013]. The Allen Mouse Brain Connectivity Atlas —...”
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