- claim_text
In mouse somatosensory cortex L5, the excitatory postsynaptic proteomes of IT and PT pyramidal neurons differ in cell-surface proteins, neurotransmitter receptors and ion channels, providing molecular signatures that align with their distinct connectivity and physiology.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41467-024-55470-w",
"claim": "In mouse somatosensory cortex L5, the excitatory postsynaptic proteomes of IT and PT pyramidal neurons differ in cell-surface proteins, neurotransmitter receptors and ion channels, providing molecular signatures that align with their distinct connectivity and physiology.",
"cite_key": "Marcassa2025",
"evidence": "In vivo cell-type-restricted proximity biotinylation of postsynaptic density proteins of L5 IT vs PT neurons in mouse somatosensory cortex.",
"effect_size": "qualitative — distinct IT vs PT synaptic proteomes",
"text_access": "abstract_only",
"study_system": "mouse somatosensory cortex L5 IT and PT neurons",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "We find distinct synaptic signatures of L5 IT and PT neurons that are defined by proteins regulating synaptic organization and transmission, including cell-surface proteins (CSPs), neurotransmitter receptors and ion channels.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-4199211be8f8"
]
- evidence_refs
[
{
"ref": "paper:paper-4199211be8f8"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}