- claim_text
Optogenetic activation of VIP interneurons in mouse auditory and prefrontal cortex specifically suppresses somatostatin and a fraction of parvalbumin interneurons, producing disinhibition of pyramidal neurons; VIP interneurons are recruited by behavioral reinforcement signals during auditory discrimination.
- raw_fields
{
"n": 0,
"doi": "10.1038/nature12676",
"claim": "Optogenetic activation of VIP interneurons in mouse auditory and prefrontal cortex specifically suppresses somatostatin and a fraction of parvalbumin interneurons, producing disinhibition of pyramidal neurons; VIP interneurons are recruited by behavioral reinforcement signals during auditory discrimination.",
"cite_key": "Pi2013",
"evidence": "VIP-Cre × Ai32 ChR2-EYFP and AAV-DIO-ChR2 in VIP-Cre with single-cell recordings in awake mice during auditory discrimination.",
"effect_size": "32",
"text_access": "fulltext",
"study_system": "VIP-Cre transgenic mice with optogenetic activation",
"source_cluster_id": "cluster_10",
"replication_status": "independently_replicated",
"claim_source_sentence": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively.",
"replication_evidence_dois": [
"10.1038/nature11526"
],
"effect_size_source_sentence": "VIP-Cre × Ai32 ChR2-EYFP and AAV-DIO-ChR2 in VIP-Cre with single-cell recordings in awake mice during auditory discrimination."
}- source_refs
[
"paper:paper-065a0eae69a5"
]
- source_span
We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively.
- evidence_refs
[
{
"ref": "paper:paper-065a0eae69a5"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}