- claim_text
Nicotinic receptor activation selectively depolarizes neocortical VIP/CCK-coexpressing interneurons while having no effect on pyramidal cells, PV fast-spiking, or SST interneurons, identifying a cell-type-specific intrinsic-excitability response distinguishing VIP cells from PV/SST.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.19-13-05228.1999",
"claim": "Nicotinic receptor activation selectively depolarizes neocortical VIP/CCK-coexpressing interneurons while having no effect on pyramidal cells, PV fast-spiking, or SST interneurons, identifying a cell-type-specific intrinsic-excitability response distinguishing VIP cells from PV/SST.",
"title": null,
"cite_key": "Porter1999",
"evidence": "rat neocortical slices, whole-cell + scRT-PCR, pharmacology (nicotine, DHβE, mecamylamine, MLA, TTX, low Ca2+)",
"effect_size": "Selective excitation in VIP+CCK+ interneurons; null effect in pyramidal/PV/SST",
"text_access": "abstract_only",
"study_system": "rat neocortex acute slices",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 3,
"claim_source_sentence": "Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.",
"replication_evidence_dois": [
"10.1093/cercor/bhw143"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-5f194b747ea7"
]
- source_span
Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.
- evidence_refs
[
{
"ref": "paper:paper-5f194b747ea7"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}