- claim_text
Abstract Vasoactive intestinal peptide (VIP), acting on both VPAC 1 and VPAC 2 receptors, is a key modulator of hippocampal synaptic transmission, pyramidal cell excitability and long-term depression (LTD), exerting its effects partly through modulation GABAergic disinhibitory circuits.
- raw_fields
{
"n": null,
"doi": "10.3390/biology11050627",
"year": "2022",
"claim": "Abstract Vasoactive intestinal peptide (VIP), acting on both VPAC 1 and VPAC 2 receptors, is a key modulator of hippocampal synaptic transmission, pyramidal cell excitability and long-term depression (LTD), exerting its effects partly through modulation GABAergic disinhibitory circuits.",
"title": null,
"journal": "Biology",
"cite_key": "Caulinorocha2022",
"evidence": "Endogenous VIP VPAC<sub>1</sub> Receptor Activation Modulates Hippocampal Theta Burst Induced LTP: Transduction Pathways and GABAergic Mechanisms",
"effect_size": "4–10 Hz",
"text_access": "fulltext",
"study_system": "rat hippocampus",
"_source_cluster": "cluster_06_disinhibition_circuit",
"snowball_origin": "forward_r2",
"replication_status": "replication_unknown",
"_source_cluster_index": 98,
"claim_source_sentence": "Abstract Vasoactive intestinal peptide (VIP), acting on both VPAC 1 and VPAC 2 receptors, is a key modulator of hippocampal synaptic transmission, pyramidal cell excitability and long-term depression (LTD), exerting its effects partly through modulation GABAergic disinhibitory circuits.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "LTP can be evoked in vitro by theta burst stimulation (TBS) [ 19 , 20 ], a sequence of electrical stimuli that mimic CA1 pyramidal cell burst firing such as that which occurs during the hippocampal theta rhythm (4–10 Hz), an EEG pattern linked to hippocampal memory storage in rodents [ 21 , 22 ]."
}- source_refs
[
"paper:paper-42bc46b763d2"
]
- source_span
Abstract Vasoactive intestinal peptide (VIP), acting on both VPAC 1 and VPAC 2 receptors, is a key modulator of hippocampal synaptic transmission, pyramidal cell excitability and long-term depression (LTD), exerting its effects partly through modulation GABAergic disinhibitory circuits.
- evidence_refs
[
{
"ref": "paper:paper-42bc46b763d2"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}